With Qube 384, Sophion’s high throughput screening system, you can make gigaseal ion channel recordings in 384 cells simultaneously enabling a massive throughput for screening, characterization, or research. With the true walk-away operation, you can efficiently utilize laboratory resources to save valuable time, while ensuring the highest success rates for your drug discovery and ion channel research.

• Giga-Ω seal ion channel recordings in 384 cells at scale
• A true walk-away screening solution to meet demanding timelines
• Accurate control of temperature, via sensor and feedback loop on the measurement site
• Unique adaptive features treat cells individually (adaptive current/voltage clamp)
• User-friendly interface ensures easy and efficient onboarding and staff rotation
• Comprehensive Analyzer software designed for easy and automated data analysis
• Database solution supports retrospective search and analysis over multiple projects and over time

Also, the unique microflow-based design of the QChips ensures consistent quality recordings time after time.

• Fast and complete liquid exchange via microfluidic channels
• Ready-to-use individual electrode pairs – no need to ever re-chloride electrodes again

Adaptive current clamp

Adaptive current clamp is a unique feature of Sophion amplifiers. The main challenge with current clamp on automated patch clamp platforms is the variation in sealing and resting membrane potential from cell to cell. This makes it impossible to design one current clamp protocol to work on all cells. We have solved that with our unique Adaptive Current Clamp feature. Read more

Adaptive voltage clamp

Adaptive voltage clamp is a unique feature of Sophion amplifiers. Optimize voltage clamp protocols individually for each cell’s electrical properties. The Qube 384 system will automatically perform Boltzmann fits for each cell online. This is to estimate the cell-specific voltage needed to activate X% of the receptor population or the voltage that keeps X% of the cells in an inactivated state. Read more

Temperature control

With the temperature control add-on, you can perform experiments at controlled physiological temperatures. Thereby, reducing fluctuations caused by temperature changes in your laboratory environment and thus ensuring higher repeatability and reproducibility. Read more

Rs compensation

100% Rs compensation is unique to Sophion solutions. Series resistance compensation for fast-activating ion channels can help remove voltage clamp errors and improve clamp accuracy. All Sophion’s patch-clamp amplifiers utilize a patented technology enabling up to 100% Rs compensation. Read more

Sophion Analyzer software

Advanced and customized analysis of your data can be performed immediately after your data has been collected. Sophion Analyzer can analyze thousands of data points automatically and present the results according to your requirements. Read more

Qube stacker and cell hotel

The Qube stacker enables you to feed compounds and QChips, and with the onboard cell hotel supplying the cells, you can now run hours of screening as unattended overnight operations, freeing up valuable research time. Read more

QChips microflow-based consumables using single & multi-hole technology

QChips are based on microfluidic principles to ensure fast and complete liquid exchange, pre-defined compound concentration, and low compound consumption. Our QChips come with one patch hole per measurement site or 10 patch holes per measurement site. QChips with 10 patch holes are ideal for high-throughput screening and can be expected to have success rates over 90%. Read more