Qube 384 – High Throughput Automated Patch Clamp

High-performance & high-throughput ion channel characterization and screening

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Sophion Qube 384 high throughput screening on ion channels

High throughput screening with Qube 384

With Qube 384, Sophion’s high throughput screening system, you can make gigaseal ion channel recordings in 384 cells simultaneously enabling a massive throughput for screening, characterization, or research. With the true walk-away operation, you can efficiently utilize laboratory resources to save valuable time, while ensuring the highest success rates for your drug discovery and ion channel research.

Qube 384 offers:

  • Giga-Ω seal ion channel recordings in 384 cells at scale
  • A true walk-away screening solution to meet demanding timelines
  • Accurate control of temperature, via sensor and feedback loop on the measurement site
  • Unique adaptive features treat cells individually (adaptive current/voltage clamp)
  • User-friendly interface ensures easy and efficient onboarding and staff rotation
  • Comprehensive Analyzer software designed for easy and automated data analysis
  • Database solution supports retrospective search and analysis over multiple projects and over time

Also, the unique microflow-based design of the QChips ensures consistent quality recordings time after time.

  • Fast and complete liquid exchange via microfluidic channels
  • Ready-to-use individual electrode pairs – no need to ever re-chloride electrodes again
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Key Qube 384 functionalities

Adaptive current clamp

Adaptive current clamp is a unique feature of Sophion amplifiers. The main challenge with current clamp on automated patch clamp platforms is the variation in sealing and resting membrane potential from cell to cell. This makes it impossible to design one current clamp protocol to work on all cells. We have solved that with our unique Adaptive Current Clamp feature. Read more

Adaptive voltage clamp

Adaptive voltage clamp is a unique feature of Sophion amplifiers. Optimize voltage clamp protocols individually for each cell’s electrical properties. The Qube 384 system will automatically perform Boltzmann fits for each cell online. This is to estimate the cell-specific voltage needed to activate X% of the receptor population or the voltage that keeps X% of the cells in an inactivated state. Read more

Temperature control

With the temperature control add-on, you can perform experiments at controlled physiological temperatures. Thereby, reducing fluctuations caused by temperature changes in your laboratory environment and thus ensuring higher repeatability and reproducibility. Read more

Rs compensation

100% Rs compensation is unique to Sophion solutions. Series resistance compensation for fast-activating ion channels can help remove voltage clamp errors and improve clamp accuracy. All Sophion’s patch-clamp amplifiers utilize a patented technology enabling up to 100% Rs compensation. Read more

Sophion Analyzer software

Advanced and customized analysis of your data can be performed immediately after your data has been collected. Sophion Analyzer can analyze thousands of data points automatically and present the results according to your requirements. Read more

Qube stacker and cell hotel

The Qube stacker enables you to feed compounds and QChips, and with the onboard cell hotel supplying the cells, you can now run hours of screening as unattended overnight operations, freeing up valuable research time. Read more

QChips microflow-based consumables using single & multi-hole technology

QChips are based on microfluidic principles to ensure fast and complete liquid exchange, pre-defined compound concentration, and low compound consumption. Our QChips come with one patch hole per measurement site or 10 patch holes per measurement site. QChips with 10 patch holes are ideal for high-throughput screening and can be expected to have success rates over 90%. Read more

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Sophion Qube 384 high throughput screening on ion channels

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  • "To speed up the process, we needed higher throughput and the ability to do more recordings at the same time. This was a key reason why we were so interested in a patch clamp robot."

    Angelika Lampert, University Professor, Principal investigator at Uniklinik RWTH Aachen

  • "We needed a machine that was flexible, simple to use, reliable, and came with easy-to-use software. The Qube met those requirements"

    Gary Clark, Director of Screening Technologies, Metrion Biosciences

  • "It’s like having 384 incredibly skilled postdocs who never get tired and never make a mistake."

    Bruce Bean, PhD, Professor of Neurobiology at Harvard Medical School

  • "The idea is to have a workflow coming from an individual pain patient and to do basic research to understand the biophysical properties of this special variant. The Qube enhances our workflow."

    Ralf Hausmann, Professor, Co-Principal Investigator at Uniklinik RWTH Aachen

  • "Using a QPatch or Qube is fairly simple. You can train someone up very quickly, within half a day, to use the instrument. In a few more days, they can generate data, conduct analysis, use the software and plot their data. "

    Gary Clark, PhD, Metrion Biosciences, Director of Screening Technologies

  • "With Qube, we can do an overall analysis and see what’s happening. We can now focus more precisely on a special feature of the channel or the mutation. It’s much faster – you look at the data and decide what your next step will be."

    Ralf Hausmann, Professor, Co-Principal Investigator at Uniklinik RWTH Aachen

Sophion customer case stories

With the help of our automated patch clamp solutions, we have asked our customers how they use the technology to shape their future.

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