AUTOMATED PATCH CLAMP QPLATES

Giga-ohm performance in physiological Ringer's solutions

QPlate, the biochip for QPatch, provides a non-compromised test environment that ensures consistent quality time after time

Unique QPlates with integrated and maintenance free electrodes for QPatch Compact & QPatch

QPlates are uniquely designed for use with QPatch Compact and QPatch. The integrated flow channels and maintenance-free integrated electrodes provides a non-compromised test environment and ensures consistent quality recordings time after time.

Dual electrodes integrated in each measurement site on the QPlate eliminates the need for electrode maintenance and the risk of electrode drift. Thereby, ensuring consistent and high-quality data recordings. Furthermore, the silicon chip substrate allows for true gigaohm seal recordings in physiological EC/IC solutions without the need for seal enhancers, which makes QPlates ideal for cardiac safety studies and stem cell research.

QPlates offer:

  • Giga-Ω seal in physiological solutions – no need for seal enhancers, or fluoride
  • Glass coated to minimize compound adsorption
  • Microflow-based to ensure 100% liquid exchange
  • Two embedded electrodes per well eliminate the risk of electrode drift and eliminate the need for electrode maintenance (re-chloridization)
  • Single- and multi-hole recordings
  • Current clamp recordings, as well as voltage- and ligand-gated

Choose your QPlate depending on your needs:

  1. QPlate 8/16/48 – single-hole per measurement site
  2. QPlate 8X/16X/48X – 10-hole per measurement site
  3. QPlate custom – varying hole sizes and number of holes

 

The QPlate is ideal for high performance measurements both ligand-gated and voltage-gated ion channel patch clamp

QPlate and QChip 384 is the advanced microfluidic flow channels that lead compounds and buffers to the cell.

QPlates and QChips are both microflow-channel based (liquid displacement method), ensuring 100% compound exchange without risk of 'overshoot concentrations' that can happen using open well technology (liquid dilution method). Both QPlates and QChips has two embedded electrodes eliminating the risk of electrode drift and eliminates the need for maintenance (re-chloridization) that takes up precious instrument uptime.

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QPlates are designed with microfluidic flow channels that deliver compounds and buffers to the intra- and extracellular part of the cell. This enables a series of liquid additions to be applied sequentially to the same cell, thus increasing throughput, and reducing cost per data point.

The microflow channel technology also means that compound trays are prepared in the correct concentrations and no dilution of compounds takes place (liquid displacement method). This has the advantage that no ‘overshoot’ concentrations will happen as can be seen using the open well technology (liquid dilution method). Using the dilution method an excess concentration of compounds is added to the wells since the compound will be diluted in the liquid already in the well.

QPlates are available in both single- and multi-hole versions. In addition, different sizes and numbers of holes (for the multi-hole QPlates) are available on request. You can use the full QPlate in one assay, or use one or more columns on the QPlate per assay depending on what is most suitable for your experiment.

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QPlate, the biochip for QPatch, provides a non-compromised test environment that ensures consistent quality time after time

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  • "For manual patch clamping, you have to practice your skills and techniques before you can generate data. It can take months before you can start generating actual usable data for grants or papers or similar purposes. Today, with QPatch, you could potentially start running it after a day of training."

    Soomin Song, PhD, Assistant Professor and Manager of the IonLab

  • "In the past, if I was lucky, I could fully test one compound for full dose responses on one ion channel in one day. Now I can test eight compounds on three ion channels and get full dose responses. It’s a huge difference."

    Nina Ottosson, Senior Research Coordinator, Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology

  • "For over a decade, we have used Sophion QPatch to support hit-to-lead and lead optimization, in addition to cardiac safety profiling. The addition of a QPatch II and a Qube 384 upgrades and extends our capacity for these efforts and now adds a Sophion platform for electrophysiology-based high-throughput screening. "

    Caterina Virginio, PhD, Evotec, Discovery Electrophysiology Senior Manager

  • "Our collaboration with Sophion and access to their expertise is a real-world example of what you can achieve with automated patch clamping and an expert supplier."

    Fredrik Elinder, Professor, Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology

  • "Using a QPatch or Qube is fairly simple. You can train someone up very quickly, within half a day, to use the instrument. In a few more days, they can generate data, conduct analysis, use the software and plot their data. "

    Gary Clark, PhD, Metrion Biosciences, Director of Screening Technologies

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