Psychiatric disorders affect many people and encompass a long list of conditions. The disorders range in severity from mild over socially debilitating to life-threatening. A growing body of evidence has established that ion channels play an important role in these diseases.
Neuronal excitability, neurotransmitter release, gene transcription and brain plasticity hinge on ion channel functionality and hence can be harmed by malfunctioning ion channels.
Key ion channels in psychiatric disorders:
- NaV1.1, 1.2 & 1.3
- KV1.1, 3.x, 7.3 & 11.1
- Kir3.1 & 4.1
- KCa1.1 & 3.1