Hit to Lead process in drug discovery
The hit to Lead stage in drug discovery is the process of transforming a lead compound (a molecule that shows potential as a drug) identified in the screening phase into a drug candidate. This involves testing the lead compound for potency, efficacy, selectivity and toxicity to generating new leads through structure-activity relationship (SAR) studies and computational drug design. During this phase, medicinal chemists and scientists develop and optimize lead compounds to improve their target-binding affinity and pharmacological properties.
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