Rs compensation add-on

Remove clamp artifacts with up to 100% serial resistance compensation

Rs compensation on Sophion platforms

Rs compensation for improved patch clamp accuracy

Using Rs compensation for fast-activating ion channels can remove voltage clamp errors and improve patch clamp accuracy.

All Sophion’s patch-clamp amplifiers utilize a patented technology enabling up to 100% Rs compensation and are equipped with automatic clip detection to avoid loss of cells due to fatal oscillations. Thereby, increasing data throughput while maintaining high-quality recordings.

Serial resistance compensation enables:

  • Remove patch clamp artefacts
  • Increase patch clamp accuracy
  • Up to 100% Rs compensation using Sophion patented algorithms
  • Automatic clip detection increases data throughput while maintaining high-quality recordings
Learn more about Rs compensation

  • "In the past, if I was lucky, I could fully test one compound for full dose responses on one ion channel in one day. Now I can test eight compounds on three ion channels and get full dose responses. It’s a huge difference"

    Nina Ottosson, Senior Research Coordinator, Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology

  • "We use the Sophion Analyzer software every day to check the quality of our cells and the variability of the results. This is important to decide if further re-runs or adaptations are necessary"

    Simon Hebeisen, PhD, B’SYS GmbH, CSO

  • "Using a QPatch or Qube is fairly simple. You can train someone up very quickly, within half a day, to use the instrument. In a few more days, they can generate data, conduct analysis, use the software and plot their data "

    Gary Clark, PhD, Metrion Biosciences, Director of Screening Technologies

  • "Sophion provides the best solution for us when it comes to system, service, and support. Thanks to a long-term collaboration, the majority of B'SYS cell lines are validated for use across Sophion’s APC platforms"

    Daniel Konrad, MD, B’SYS GmbH, CEO

  • "Our collaboration with Sophion and access to their expertise is a real-world example of what you can achieve with automated patch clamping and an expert supplier"

    Fredrik Elinder, Professor, Linköping University, Department of Biomedical and Clinical Sciences, Division of Neurobiology

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