QChips are uniquely designed for use with Qube 384. The integrated flow channels and maintenance-free integrated electrodes provides a non-compromised test environment and ensures consistent quality recordings time after time.

With QChips, cells seal tightly onto planar surfaces performing true gigaseal, and liquids can be handled efficiently in 384-format microfluidic channels. Thereby, ensuring consistent and high-quality data recordings.

• Single- and multi-hole
• Microflow-based to ensure 100% liquid exchange
• 384 Integrated electrode pairs eliminate the risk of electrode drift and eliminate the need for electrode maintenance (re-chloridization)
• Capable of long (> 1 hour) experiments with no electrode drift
• Current clamp recordings, as well as voltage- and ligand-gated

1. QChip 384 –   single-hole per measurement site
2. QChip 384X – 10-hole per measurement site
3. QChip 384D – Varying number of holes per measurement site
4. QChip 384C – Custom number of holes and hole sizes per measurement site

QChips are designed with microfluidic flow channels that deliver compounds and buffers to the intra- and extracellular part of the cell. This enables a series of liquid additions to be applied sequentially to the same cell, thus increasing throughput, and reducing cost per data point.

The microflow channel technology also means that compound trays are prepared in the correct concentrations and no dilution of compounds takes place (liquid displacement method). This has the advantage that no ‘overshoot’ concentrations will happen as can be seen using the open well technology (liquid dilution method). Using the dilution method an excess concentration of compounds is added to the wells since the compound will be diluted in the liquid already in the well.

QChips are available in both single- and multi-hole versions.