Program

Tuesday 17 October

Time Title Presenter
6.30-7.30 PM Dean's Distinguished Lecture Series, Community Lecture
How do you feel? Molecules that sense touch
Prof. Ardem Patapoutian - Scripps Research, Howard Hughes Medical Institute

Wednesday 18 October

Time Title Presenter
8:00 AM Registration
8:45 AM Welcome remarks Thais T Johansen, CEO, Sophion Bioscience A/S - Michael Stamos, MD, Dean, UCI School of Medicine - Geoffrey Abbott, PhD, Vice Dean, Basic Science Research, UCI School of Medicine
9:00 AM Session 1 Chair: Prof. Geoffrey Abbott - University of California, Irvine
9:00 AM The role of PIEZO ion channels in sensory biology Dean's Distinguished Lecture Series

KEYNOTE:
Prof. Ardem Patapoutian - Scripps Research, Howard Hughes Medical Institute
10:00 AM Function and regulation of HCN4 ion channels in cardiac pacemaking Prof. Cathy Proenza - University of Colorado
10.25 AM Tuning cooperativity in NMDA receptors Prof. Ehud Isacoff - University of California, Berkeley
10:50 AM Tea/coffee - exhibits and posters
11:30 AM Session 2 Chair: Prof. Heike Wulff - University of California, Davis
11:30 AM The structural basis of divalent cation block in a tetrameric prokaryotic sodium channel Professor Katsumasa Irie - Wakayama Medical University
11:55 AM KCNA6 channelopathies Ms. Valentina Galassi Deforie - University College London
12:20 PM Ion channel modulation by small molecule toxins and large protein complexes Prof. Fayal Abderemane-Ali - University of California, Los Angeles
12:45 PM Lunch - exhibits and posters
1:45 PM Session 3 Chair: Dr. Daniel Sauter - Sophion Bioscience
1:45 PM Structures of the CLC-2 chloride channel Prof. Merritt Maduke - Stanford University
2:10 PM Targeting KCa1.1 (BK) channels in synovial fibroblasts for the treatment of rheumatoid arthritis Prof. Christine Beeton - Baylor University
2:35 PM APOL1 inhibition as a treatment option for ApoL1 genetic variant associated nephropathies Dr. Neil Castle - OmniAb, Inc. - Icagen Ion Channel Technology
03:00 PM Tea/coffee - exhibits and posters
4:00 PM Session 4 Chair: Dr. Joseph McGivern - Cytokinetics
4:00 PM Unlocking the therapeutic potential of lysosomal ion channels Dr. Xiang Wang - Denali Therapeutics
4:25 PM Structural insights into the heteromeric assembly of epithelial sodium channels Dr. Isabelle Baconguis - Vollum Institute
4:50 PM Sophion Bioscience: News & Views Thomas Binzer - VP Research & Development, Sophion Bioscience A/S
5:15 PM Wrap-up Duncan Jarman - Sales Manager, Sophion Bioscience A/S
05:30 PM Drinks reception

Thursday 19 October

Time Title Presenter
9:00 AM Welcome remarks
9:05 AM Session 5 Chair: Prof. Merritt Maduke - Stanford University
9:05 AM Channels as Therapeutic Targets for Acute Life-threatening Disease Prof. Steve Goldstein - University of California, Irvine
9:30 AM Small-molecule modulation of Kir4.1/Kir5.1 channel function for treating fluid-balance disorders Prof. Jerod Denton - Vanderbilt University
9:55 AM Potassium channel-targeted small molecule discovery from plants Prof. Geoffrey Abbott - University of California, Irvine
10:20 AM GABAA Receptor Pharmacology Revisited: Rat Poison and Plastic Explosive Prof. Heike Wulff - University of California, Davis
10:45 PM Tea/coffee - exhibits and posters
11:45 AM Session 6 Chair: Prof. Geoffrey Abbott - University of California, Irvine
11:45 AM Ion channels in T cells as therapeutic targets Prof. Mike Cahalan - University of California, Irvine
12:10 PM Gating and pharmacology of OTOP proton channels Prof. Emily Liman - University of Southern Calfornia
12:35 PM Asymmetric roles for M2-M3 linkers in GABAA receptor pore gating and drug modulation Prof. Marcel Goldschen-Ohm - University of Texas, Austin
1:00 PM Lunch - exhibits and posters
2:00 PM Session 7 Chair: Prof. Merritt Maduke - Stanford University
2:00 PM Towards more physiological assays: Neurological models using automated patch clamp platforms (Qube 384 & QPatch II) Dr Daniel Sauter - Sophion Bioscience Inc.
2:25 PM Structure-function study of KCa2.x channels Prof. Miao Zhang - Chapman University
2:50 PM Molecular Choreography of Piezo1 during Development and Repair Prof. Medha Pathak - University of California, Irvine
3:15 PM Light-activated TREK potassium channel to remote control pain in freely moving animals Dr. Guillaume Sandoz - Université Côte d'Azur
3:40 PM Wrap up & closing remarks Thomas Binzer - VP Research & Development, Sophion Bioscience A/S