The Nav1.5 ion channel current is one of five currents that generates and maintains the cardiac action potential that drives our heartbeat. Consequently, recording Nav1.5 activity in human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CM) is critical in understanding the physiology and pharmacology of this channel, and its key role in the heart.

In our latest application report, we test Fujifilm Cellular Dynamics iCell© cardiomyocytes. We have generated a consistent and repeatable assay for biophysical and pharmacological characterization on the Sophion QPatch platform.

In this report, we highlight the iCell© cardiomyocytes with our new assay to be effective and efficient for Nav1.5 ion channel characterization, making a useful addition to our growing armory for cardiac physiology and safety pharmacology studies.