Qube 384 with stacker for unattended operation making drug discovery fast and efficient

High throughput ion channel screening made easy

Qube 384

Qube 384, Sophion’s high throughput screening system, is our way of making ion channel research easy. Combining giga-seal recordings with true walk-away operation is a strong tool in making drug discovery more efficient. Qube is high fidelity voltage clamp where each cell can be clamped at its own V½-potential to better elucidate compound mode-of-action. The temperature can be controlled at the cellular level and both heated and cooled. The temperature value is also available for the subsequent analysis.

Qube finally bridges the gap between high throughput and high fidelity in ion channel assays and provides:

  • Online V½ estimation
  • 90-95% success rates easily achieved (E.g. hERGNaV1.4, CaV1.2)
  • True walk-away operation – 6,000 wells tested with a single click
  • All ion channel questions answered with voltage, ligand and current clamp recordings
  • Gigaseal recording ensure high fidelity data and high signal to noise ratio
  • Temperature control
  • Intelligent compound handling to ensure correct concentrations at measurement site
  • Enables staff rotation with easy to use assay setup interface
  • Powerful analysis with Sophion Analyzer Software
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