DAY 1 – WEDNESDAY
08.00Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Registration and tea/coffee
09.00Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Â Welcome remarks
Session 1 – Professor David Wyllie, Edinburgh University
09.15         Professor Matthew Nolan – Edinburgh University
Diverse computational roles for HCN1 ion channels in behaviour
09.40          Dr Hongjie Yuan – Emory University
GRIN mutations in neurological diseases: from molecular mechanism to rescue pharmacology
10.05         Dr Stephen Brickley – Imperial College London (ICL)
Age-related changes in synaptic transmission during cognitive decline
10.30         Tea/coffee – exhibits and posters
11.15          Professor Hirokazu Hirai – Gunma University Graduate School of Medicine
GABA-B receptor and type 1 metabotropic glutamate receptor (mGluR1) as therapeutic targets for hereditary spinocerebellar ataxia
11.40          Professor Jian Yang – Columbia University
Antiarrhythmic natural compounds and structural basis of modulation of an endolysosomal calcium channel
12.05          Professor Lucia Sivilotti – University College London (UCL)
Agonist efficacy in Cys-loop ion channels: the single molecule view
12.30Â Â Â Â Â Â Â Â Â Lunch
Session 2 – Professor Derek Bowie – McGill University
14.00         Professor Annette Dolphin – University College London (UCL)
Neuronal calcium channel trafficking and function: relevance to chronic pain
14.25         Professor Yasuo Mori – Kyoto University
Redox biology of TRP channels
14.50         Professor Uwe Rudolph – McLean Hospital and Harvard University
Towards a circuit-based pharmacology of GABAA receptors
15.15         Tea/coffee – exhibits and posters
16.00         Asst. Professor Saviero Gentile – Loyola University of Chicago
ONK+O targeting: Pharmacological stimulation of K+Â channel activity as novel and safe anticancer strategy
16.25          Professor Diane Lipscombe – Brown University
Cell-specific splicing of neural calcium ion channels modulates activity and drug
16.50         Professor Anders Jensen – Copenhagen University
Probing the molecular basis for potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAAÂ receptors
17.15Â Â Â Â Â Â Â Â Â Wrap-up
17.30         Drinks reception in the Scholar’s Garden
18.30Â Â Â Â Â Â Â Â Â Dinner in the Great Hall of Clare College
DAY 2 – THURSDAY
08.00Â Â Â Â Â Â Â Â Â Tea/Coffee
09.00Â Â Â Â Â Â Â Â Â Welcome Remarks
Session 3 – Chair Professor Stephen Tucker – Oxford University
09.05         Professor David Beech – Leeds University
Piezo1 channel function and small-molecule modulation
09.30         Professor David Bennett – University of Oxford
The role of NaV1.7 in human pain disorders
09.55         Professor Jun-ichi Okada – University of Tokyo
Cardiac safety assessment of drugs based on a hybrid system combining automated patch clamp and heart simulator
10.20Â Â Â Â Â Â Â Â Â Tea/Coffee, Exhibits and Posters
11.20         Professor Bonnie Wallace – Birkbeck, University of London
Voltage-gates sodium channels: structure, function and disease
11.45         Professor Dr. Gary Lewin – Max Delbruck Center
Modulating force sensing channels by voltage and small molecules
12.10         Professor Nikita Gamper – Leeds University
Modulation of KV7 potassium channels by intracellular zinc
12.35Â Â Â Â Â Â Â Â Â Lunch
Session 4 – Chair Professor Martin Gosling – Sussex University
14.00         Professor Thomas Jentsch – Max Delbrueck Center for Molecular Medicine
The volume regulated anion channel VRAC: structure-function and surprising roles
14.25         Professor David Sheppard – Bristol University
Cystic fibrosis: rescuing defective chloride channels with small molecules
14.50         Associate Professor Bo Hjorth Bentzen – Copenhagen University
Modulation and anti-arrhythmic potential of SK channels
15.15         Professor Raimund Dutzler – Zurich University
The mechanism of ion conduction and gating in the calcium-activated chloride channel TMEM16A
15.40Â Â Â Â Â Â Â Â Â Wrap Up