08.00                  Registration and tea/coffee


09.00                  Welcome remarks


Session 1 – Professor David Wyllie, Edinburgh University

09.15                  Professor Matthew Nolan – Edinburgh University

Diverse computational roles for HCN1 ion channels in behaviour


09.40                  Dr Hongjie Yuan – Emory University

GRIN mutations in neurological diseases: from molecular mechanism to rescue pharmacology


10.05                 Dr Stephen Brickley – Imperial College London (ICL)

Age-related changes in synaptic transmission during cognitive decline


10.30                  Tea/coffee – exhibits and posters


11.15                  Professor Hirokazu Hirai – Gunma University Graduate School of Medicine

GABA-B receptor and type 1 metabotropic glutamate receptor (mGluR1) as therapeutic targets for hereditary spinocerebellar ataxia


11.40                   Professor Jian Yang – Columbia University

Antiarrhythmic natural compounds and structural basis of modulation of an endolysosomal calcium channel


12.05                  Professor Lucia Sivilotti – University College London (UCL)

Agonist efficacy in Cys-loop ion channels: the single molecule view


12.30                  Lunch


Session 2 – Professor Derek Bowie – McGill University

14.00                  Professor Annette Dolphin – University College London (UCL)

Neuronal calcium channel trafficking and function: relevance to chronic pain


14.25                  Professor Yasuo Mori – Kyoto University

Redox biology of TRP channels


14.50                  Professor Uwe Rudolph – McLean Hospital and Harvard University

Towards a circuit-based pharmacology of GABAA receptors


15.15                  Tea/coffee – exhibits and posters


16.00                  Asst. Professor Saviero Gentile – Loyola University of Chicago

ONK+O targeting: Pharmacological stimulation of K+ channel activity as novel and safe anticancer strategy


16.25                  Professor Diane Lipscombe – Brown University

Cell-specific splicing of neural calcium ion channels modulates activity and drug


16.50                  Professor Anders Jensen – Copenhagen University

Probing the molecular basis for potency- and efficacy-based subtype-selectivity exhibited by benzodiazepine-site modulators at GABAA receptors


17.15                  Wrap-up

17.30                  Drinks reception in the Scholar’s Garden

18.30                  Dinner in the Great Hall of Clare College


08.00                  Tea/Coffee

09.00                  Welcome Remarks


Session 3 – Chair Professor Stephen Tucker – Oxford University

09.05                  Professor David Beech – Leeds University
Piezo1 channel function and small-molecule modulation


09.30                  Professor David Bennett – University of Oxford
The role of NaV1.7 in human pain disorders


09.55                  Professor Jun-ichi Okada – University of Tokyo
Cardiac safety assessment of drugs based on a hybrid system combining automated patch clamp and heart simulator


10.20                  Tea/Coffee, Exhibits and Posters


11.20                  Professor Bonnie Wallace – Birkbeck, University of London
Voltage-gates sodium channels: structure, function and disease


11.45                  Professor Dr. Gary Lewin – Max Delbruck Center
Modulating force sensing channels by voltage and small molecules


12.10                  Professor Nikita Gamper – Leeds University
Modulation of KV7 potassium channels by intracellular zinc


12.35                  Lunch


Session 4 – Chair Professor Martin Gosling – Sussex University

14.00                  Professor Thomas Jentsch – Max Delbrueck Center for Molecular Medicine
The volume regulated anion channel VRAC: structure-function and surprising roles


14.25                  Professor David Sheppard – Bristol University
Cystic fibrosis: rescuing defective chloride channels with small molecules


14.50                  Associate Professor Bo Hjorth Bentzen – Copenhagen University
Modulation and anti-arrhythmic potential of SK channels


15.15                  Professor Raimund Dutzler – Zurich University
The mechanism of ion conduction and gating in the calcium-activated chloride channel TMEM16A


15.40                  Wrap Up