The unique and intelligent pressure system on the QPatch Compact and QPatch ensures that each well is treated independently during whole-cell formation. Just like manual patch clamping. We call it adaptive whole-cell protocols, and these provide:

• high success rates
• higher throughput
• lower cost per datapoint

Adaptive whole-cell protocols adjust the pressure individually during whole-cell formation to ensure the highest possible success rates during experiments. In contrast, other APC systems in the market are using “timed” protocols that use the same pressure protocol simultaneously on all wells (and cells). You can, of course, choose to use ‘timed’ protocols if you want to.

This does not significantly affect straightforward protocols with “easy” cell lines. However, for more complicated assays on cell lines that are more difficult to “persuade” into whole-cell mode, the adaptive whole-cell protocols significantly increase success rates, throughput and lower cost per data point.