Developing iPSC ion channel recordings with automated patch clamp
Induced pluripotent stem cell (iPSC) techniques have been developing over the last few years, improving cell differentiation and maturation. In combination with improved culturing and handling, iPSC ion channel recordings via automated patch clamp (APC) have made these model ‘adult’ differentiated cells extremely useful in biomedical research, more translatable in defining human physiology and disease, whilst reducing the need and use of animal tissue.
Over 2022, Sophion scientists, collaborators, and users of our platforms have been at the forefront of this iPSC and APC revolution. Our collaborative research is captured here:
Mike Hendrickson, BrainXell & Daniel Sauter, Sophion Bioscience on iPSC-motor neurons:
Liz Buttermore, Human Neuron Core, Boston Children’s Hospital & Kadla Rosholm, Sophion Bioscience on iPSC-cortical neurons:
Will Seibertz, University Medical Center Göttingen & Kadla Rosholm, Sophion Bioscience on iPSC-cardiomyocytes:
Adventures and Advances in Time Travel With Induced Pluripotent Stem Cells and Automated Patch Clamp
Rosholm et al., Frontiers Mol. Neurosci., 2022.