Voltage-gated sodium channels: Multi-faceted involvement in cancer


ICMS 2022 UK


Serife Yerlikaya, Scott P. Fraser and Mustafa B. A. Djamgoz



A substantial body of in vitro and in vivo evidence suggests that de novo expression of voltage-gated sodium channels (VGSCs) occurs in several carcinomas and drives the metastatic process (Djamgoz et al. 2019). It is well known that chemotherapy can lead to peripheral neuropathy, and this could be associated with an alteration in VGSC expression/activity. We questioned whether blocking VGSC activity would affect the cytotoxic impact of paclitaxel (PTX) upon human strongly metastatic MDA-MB-231 cells.

Go to journal

Get in Touch

We strive to provide the best for our customers, and we are always ready to help. Please let us know if you have a question for us.

Follow us