Voltage and current clamp recordings of Cor.4U® human iPS cell-derived cardiomyocytes using Sophion’s QPatch
Journal
Sophion application report
Author(s)
Year
2018
- High fidelity voltage and current clamp recordings of Cor.4U in physiological solution
- Demonstration of the presence of INa, ICa as well as IKr
- The use of fluoride in the internal solution resulted in lower
ICa and shortened action potential durations - Paced and spontaneous action potentials
- Pharmacological agents show expected effects on action
potentials in Cor.4U