Sodium Currents in Naïve Mouse Dorsal Root Ganglion Neurons: No Major Differences between Sexes.


Channels (Austin, Tex.) 18, no. 1 (2024): 2289256


Ghovanloo, Mohammad Reza, Sidharth Tyagi, Peng Zhao, Philip R. Effraim, Sulayman D. Dib-Hajj, and Stephen G. Waxman



Sexual dimorphism has been reported in multiple pre-clinical and clinical studies on pain. Previous investigations have suggested that in at least some states, rodent dorsal root ganglion (DRG) neurons display differential sex-dependent regulation and expression patterns of various proteins involved in the pain pathway. Our goal in this study was to determine whether sexual dimorphism in the biophysical properties of voltage-gated sodium (Nav) currents contributes to these observations in rodents. We recently developed a novel method that enables high-throughput, unbiased, and automated functional analysis of native rodent sensory neurons from naïve WT mice profiled simultaneously under uniform experimental conditions. In our previous study, we performed all experiments in neurons that were obtained from mixed populations of adult males or females, which were combined into single (combined male/female) data sets. Here, we have re-analyzed the same previously published data and segregated the cells based on sex. Although the number of cells in our previously published data sets were uneven for some comparisons, our results do not show sex-dependent differences in the biophysical properties of Nav currents in these native DRG neurons.

Keywords: Q4 2023

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