TOPIC

Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform

Journal

Journal of Pharmacological and Toxicological Methods

Author(s)

Donglin Guo & Stephen Jenkinson

Year

2019

High throughput in vitro profiling of the cardiac NaV1.5 peak sodium current (INa) is widely used in cardiac safety screening. However, there is no standardized high throughput method to measure late INa. This study assessed the pharmacological and biophysical properties of veratridine and ATX-II, as well as the channel mutation (NaV1.5-∆KPQ) on the late INa. We describe a method for simultaneous measurement of both peak and late INa.

Go to journal

Get in Touch

We strive to provide the best for our customers, and we are always ready to help. Please let us know if you have a question for us.

Follow us