Reliable Kv2.1 assasy and pharmacology on the QPatch


Sophion application report


Melanie Schupp, Lars D Løjkner



The voltage-gated potassium channel KV2.1 is the main contributor to the delayed rectifier potassium current in neurons and in the cortex (Du et al. 1998, Murakoshi et al. 1999). It has been suggested that KV2.1 activation confers neuroprotection in a state of neuronal hyperexcitability via hyperpolarizing the membrane potential (Du et al. 2000, Misonou et al. 2005, Misonou et al. 2005a). Therefore, KV2.1 may be an attractive target in epilepsy research. Also, the ion channel has previously been shown to play a central role in neurodegeneration, ageing and pancreatic β cell signaling.

Go to journal

Get in Touch

We strive to provide the best for our customers, and we are always ready to help. Please let us know if you have a question for us.

Follow us