Pharmacological evaluation of GABAA receptor subtypes on Qube 384


Application Report


Kim Boddum, Mads P G Korsgaard



Studies of GABAA ion channels using the automated patch clamp platform Qube 384 with focus on:

  • Short ligand exposure with repetitive stimulations with EC50
    concentrations of GABA
  • Effects of agonists, antagonists and modulators
  • Cumulative and non-cumulative concentration-response relationships
  • Characterizing the pharmacological properties of four cell lines expressing different GABAA subtypes
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