Pharmacological evaluation of GABAA receptor subtypes on Qube 384
Journal
Application Report
Author(s)
Year
2019
Studies of GABAA ion channels using the automated patch clamp platform Qube 384 with focus on:
- Short ligand exposure with repetitive stimulations with EC50
concentrations of GABA - Effects of agonists, antagonists and modulators
- Cumulative and non-cumulative concentration-response relationships
- Characterizing the pharmacological properties of four cell lines expressing different GABAA subtypes