Novel patch clamp assays to advance pain research




Daniel Sauter, Reza Ghonvanloo



In recent years, there has been a growing interest in the role of ion channels in pain signaling, particularly in the context of chronic pain conditions. Researchers have identified a number of ion channels that are involved in the sensation of pain, including the transient receptor potential (TRP) channels and the voltage-gated sodium channels (NaV). Understanding the mechanisms by which these channels contribute to pain signaling is a key step in developing new and more effective pain therapies.

In this webinar, attendees will gain insight into the realm of automated patch clamp assays, exploring the mechanisms of pain. First, Daniel Sauter from Sophion Bioscience will offer an overview, highlighting assays for typical pain targets recombinantly expressed in model cells and a concise introduction to the utilization of iPSC-derived DRG neurons in pain research. Dr Reza Ghovanloo from Yale Medical School will present a groundbreaking study on recording currents from freshly isolated DRG neurons.

Keywords: Current clamp

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