NMDA Receptor Modulators in QPatch


ICMS 2018 UK


Ezio Bettini, Laura Aldegheri, Laura Castelletti, Mauro Corsi and Caterina Virginio



N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors permeable to Ca2+, Na+ and K+. To be activated, they need to bind to glutamate (via GluN2 subunits), glycine (via GluN1) and release the Mg2+ blockade by
membrane depolarization. The majority of NMDARs are tetrameric complexes, consisting of two glycine-binding GluN1 subunits and two glutamate-binding GluN2 subunits. GluN1 is coded by a single gene with at least eight different splice variants; four different GluN2 genes originate GluN2A, GluN2B, GluN2C, and GluN2D subunits. NMDARs containing different GluN2 subunits have different pharmacological and kinetic properties.

NMDA receptor modulators can be studied using a variety of techniques.

Go to journal

Get in Touch

We strive to provide the best for our customers, and we are always ready to help. Please let us know if you have a question for us.

Follow us