hiPSC-derived cardiomyocytes – Nav1.5 compound screening on QPatch® II


Application Report


Beatrice Badone, Stefania Karatsiompani



The NaV1.5 channel is critical in maintaining the physiological electrical function in cardiomyocytes, as it is the heart’s main depolarising current. Here we focus on the NaV1.5 channel in human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) as an important target for cardiac-drug and safety screening.

• The hiPSC-CMs NaV1.5 compound screening was performed with assay success rate (quality filters) up to 60% and ~ 20 useful experiments per 48 recording site plate.

• The study demonstrates that it is possible to screen compounds on hiPSC-CMs using the QPatch II.

• The experimental success rate of hiPSC-CMs assays was variable depending on the quality and maturation of the cell population.

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