High throughput screening for mode-of-action on Nav1.7


Application Report


Daniel Sauter



  • Constantly high success rates (99% in 3 experiments)
  • Giga-ohm seal resistances in almost all wells
  • Very low data spread
    • All CV values of DMSO control below 10%
    • No false positives with cutoff criteria 3 X SD
    • Z’ constantly greater 0.75
  • Discrimination between different modes of inhibition (state-dependency)
  • Up to 384 individual IC50 values (3072 data points) determined in just one experiment
  • Using Qube in combination with Stacker it would be possible to determine up to 7680 IC50 (60,000 data points) per 24 hours
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