High throughput electrophysiological screen of large molecules: evaluating snake neurotoxins and the neutralization potential of recombinant antibodies


SfN 2021


Kim Boddum, Line Ledsgaard, Marie Louise Busk, Damian Bell and Andreas Laustsen Kiel



Engineered human IgG could neutralise venom derived neurotoxins

The potency of IgGs could be distinguished using APC

Broader neutralization capacity could be detected

QPatch II and Qube are well suited for efficiently characterizing both peptide toxins and antibody function


Keywords: Large molecules

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