HEK293-Cav2.2 for QPatch


Application report


Rasmus Bjørn Jacobsen



It is common that potential customers ask Sophion Bioscience to use QPatch to test some of their compounds on specific ion channels before buying a system. In this application report, we present some of the results obtained from a validation study done for a pharmaceutical company. Currents from the N-type
voltage-gated calcium channels (CaV2.2) were studied using
QPatch. A blocker of the CaV2.2 current, compound A, was
applied in increasing concentrations to study the dose-response
effects and estimate IC50 values. Furthermore, flunarizine which is known to block T-type Ca2+/Na+ channels and have low potency on N-type Ca channels, was tested.

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