TOPIC

ESCRT proteins as targets for novel antipsychotic drugs

Journal

ICMS Tokyo

Author(s)

Shalaby M, Kantamneni S, McLean SL

Year

2024

Hypothesis:

Hypofunction of NMDARs in neurons is a convergent mechanism of major genetic and/or environmental risks, leading to schizophrenia.

Knocking down of Tsg101 or silencing of Vps4a will decrease the degradation of NMDARs and increase the recycling and signalling of the receptors.

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