CHO-Nav1.5 on QPatch

The sodium ion channel Na_v1.5 is expressed as in integral membrane protein and contains a tetrodotoxin-resistant voltage-gated sodium channel subunit.The encoded protein is found primarily in cardiac muscle and is responsible for the initial upstroke of the action potential in an electrocardiogram. Mutations in the gene are associated with long QT syndrome type 3, Brugada syndrome, primary cardiac conduction disease and idiopathic ventricular fibrillation.