Analyzing the developmental profile & physiological function of neuronal Kv7 channels

Kv7 (KCNQ or M-) channels generate voltage dependent K⁺ currents and represent the molecular basis of the M-current (IM). The five known subtypes (Kv7.1-7.5) are characterized by different tissue expression and physiological properties. In most neurons, native M-channels are composed of Kv7.2 and Kv7.3 subunits, and are responsible for controlling the neuronal excitability. During physiological as well as pathophysiological conditions (e.g. epilepsy) channel modulators play a significant role. Previous studies from our group point out the importance of M-channels in the thalamocortical system, making them interesting targets for further investigation.

With this project, we thus aim to investigate: including PIP2 and cholesterol analogues. 3) The properties of IM in prethalamic/ thalamic neurons in health and disease.