Publications - Sophion

Wnts control membrane potential in mammalian cancer cells

Author(s): Jonathan Ashmore, Hervør Olsen, Naja Sørensen, Christopher Thrasivoulou, Aamir Ahmed

Wnt peptides control mammalian cancer cell membrane potential

Author(s): Jonathan Ashmore, Hervør Olsen, Naja Sørensen, Chris Thrasivoulou , Aamir Ahmed

Voltage-gated sodium channels on QPatch

Author(s): M Knirke Jensen, Hervør L Olsen

Voltage-Gated Ion Channels in Cancer Cell Proliferation

Author(s): Vidhya R. Rao 1 , Mathew Perez-Neut 1, Simon Kaja 2 and Saverio Gentile 1,*

Voltage- and current clamp on induced pluripotent cardiomyocytes with automated patch clamp

Author(s): Daniel Sauter, Anders Lindqvist, Rasmus Bjørn Jacobsen, Jens Henneke, Mads P.G. Korsgaard

Voltage and current clamp recordings of Cor.4U® human iPS cell-derived cardiomyocytes using Sophion’s QPatch

Author(s): Daniel Sauter

VHalf adaptive protocols on Qube

Author(s): Juha Kammonen, Mads P G Korsgaard

Verification of CiPA Recommended Voltage Protocols in Patch-Clamp Assay for hERG, Cav1.2 and Late Nav1.5 Currents

Author(s): Yoshimi KATAYAMA, Hiroshi MATSUKAWA, Tomokazu KANEHISA, Ayane ABE, Takashi YOSHINAGA, Keiichi ASAKURA, Kimihito YOSHIKAWA, Kazuya TSURUDOME, Tadaaki TSUKAMOTO

Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs

Author(s): Chun Yuen Chow, Yanni K.-Y. Chin, Andrew A. Walker, Shaodong Guo, Linda V. Blomster, Micaiah J. Ward, Volker Herzig, Darin R. Rokyta, and Glenn F. King

Validation of ligand-gated ion channels in multi-hole mode on QPatch

Author(s): Jacobsen et al, 2012

Validation of B’SYS KV3.x cell lines using automated and manual patch-clamp electrophysiology

Author(s): Ellen Braksator, Martina Bamberg, Jonathan Schuster, Julie Coulot, Daniel Konrad

Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia

Author(s): Damian Bell, Mark Dallas

Use- and state-dependent Nav1.5 blockers on QPatch X and in vivo and in vitro assays

Author(s): M Knirke Jensen, Tomoko Sakakura, Yasuyuki Abe, Hideo Takamori, Kiyoshi Takasuna, Yuji Tsurubuchi, Morten Sunesen

Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery

Author(s): M Asmild, N Oswald, KM Krzywkowski, S Friis, RB Jacobsen, D Reuter, R Taboryski, J Kutchinsky, RK Vestergaard, RL Schrøder, CB Sørensen, M Bech, MP Korsgaard, NJ Willumsen

TRPM8 cold sensitive ion channels

Author(s): Jensen et al., 2012

TRP’ing in multi-hole mode

Author(s): Rasmus B Jacobsen, Hervør L Olsen

Transient expression of the NMDA receptor in HEK cells co-expressing the glutamate transporter for the screening of potential positive allosteric modulators of NR2B

Author(s): Michael J Morton, John Malone, Paul Sharpe, Graham Sproat, Malcolm Haddrick, Joe Mather

Towards more physiological assays: iPSC-derived neurons tested on the 384 channel automated patch clamp platform Qube.

Author(s): Daniel Sauter

TMEM16A on Qube 384

Author(s): Joseph G. McGivern*, John K. Sullivan*, Kathryn A. Henckels*, Paul Wang*, David Powers*, Daniel Sauter**, Lars Løjkner**, Rasmus Jakobsen**, Mads Korsgaard**

TMEM16A on Qube

Author(s): Sauter, D

The sodium channel activator Lu AE98134 normalizes the altered firing properties of fast spiking interneurons in Dlx5/6+/− mice

Author(s): Nadia Lybøl von Schoubye, Kristen Frederiksen Uffe Kristiansen, Anders Victor Petersend, Nils Ole Dalby, Morten Grunnet, Henrik Sinda Jensen, Thomas Jespersen, Vikaas S. Sohale, Jean-François Perrier

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake

Author(s): Daryl C. Yang 1,2,†, Jennifer R. Deuis 3,†, Daniel Dashevsky 2,†, James Dobson 2,†, Timothy N. W. Jackson 2, Andreas Brust 3, Bing Xie 4, Ivan Koludarov 2, Jordan Debono 2, Iwan Hendrikx 2, Wayne C. Hodgson 1, Peter Josh 5, Amanda Nouwens 5, Gregory J. Baillie 3, Timothy J. C. Bruxner 3, Paul F. Alewood 3, Kelvin Kok Peng Lim 6, Nathaniel Frank 7, Irina Vetter 3,8,* and Bryan G. Fry 2,*

The intermediate conductance Ca2+ – activated K+ channel on Qube 384

Author(s): Sauter et al., 2017

The Inosine Monophosphate Dehydrogenase, GuaB2, Is a Vulnerable New Bactericidal Drug Target for Tuberculosis

Author(s): Vinayak Singh†, Stefano Donini‡, Angela Pacitto§, Claudia SalaΔ, Ruben C. HartkoornΔ, Neeraj DharΔ, Gyorgy Keri⊥, David B. Ascher§, Guillaume Mondésert#, Anthony VocatΔ, Andréanne LupienΔ, Raphael SommerΔ, Hélène Vermet#, Sophie Lagrange#, Joe Buechler⊗, Digby F. Warner†, John D. McKinneyΔ, Janos Pato⊥, Stewart T. ColeΔ, Tom L. Blundell§, Menico Rizzi‡, and Valerie Mizrahi*†

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

Author(s): Mathilde R. Israel, Panumart Thongyoo, Jennifer R. Deuis, David J. Craik, Irina Vetter, Thomas Durek

The development of automated patch clamp assays for canonical transient receptor potential channels TRPC3, 6, and 7

Author(s): McPate M, Bhalay G, Beckett M, Fairbrother S, Gosling M, Groot-Kormelink PJ, Lane R, Kent T, Van Diepen MT, Tranter P, Verkuyl JM.

Termination of Vernakalant-Resistant Atrial Fibrillation by Inhibition of Small-Conductance Ca2+-Activated K+ Channels in Pigs

Journal: Circulation: Arrhythmia and Electrophysiology
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Author(s): Jonas Goldin Diness, Lasse Skibsbye, Rafel Simó-Vicens, Joana Larupa Santos, Pia Lundegaard, Carlotta Citerni, Daniel Rafael Peter Sauter, Sofia Hammami Bomholtz, Jesper Hastrup Svendsen, Søren-Peter Olesen, Ulrik S. Sørensen, Thomas Jespersen, Morten Grunnet, Bo Hjorth Bentzen

Temperature effect on hERG channel pharmacology measured using the Qube automated patch clamp system

Author(s): Anders Lindqvist, Mette Christensen, Rasmus Jacobsen, Göran Mattson

Temperature control on Qube 384 – pharmacological dependency of hERG reference compounds

Author(s): R Jacobsen

Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers

Author(s): Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon and Richard J. Lewis

Synthesis and Biological Evaluation of Novel Olean-28,13?- lactams as Potential Anti-prostate Cancer Agents

Author(s): Yong Ai†‡, Yang Hu†, Fenghua Kang†‡, Yisheng Lai†‡, Yanju Jia†, Zhangjian Huang*†‡, Sixun Peng†‡, Hui Ji*†, Jide Tian§, and Yihua Zhang*†‡

Synthesis and biological evaluation of novel 6,11-dihydro-5H-benzo[e]pyrimido- [5,4-b][1,4]diazepine derivatives as potential c-Met inhibitors

Author(s): Daowei Huang, Lei Huang, Qingwei Zhang, Jianqi Li a

Synthesis and Biological Evaluation of Five‐Atom‐Linker‐Based Arylpiperazine Derivatives with an Atypical Antipsychotic Profile

Author(s): Chunhui Wu, Yu Wang, Feipu Yang, Wenqiang Shi, Zhen Wang, Ling He, Yang He, Jingshan Shen

Synthesis and biological evaluation of a series of multi-target N-substituted cyclic imide derivatives with potential antipsychotic effect

Author(s): Mingshuo Xu, Yu Wang, Feipu Yang, Chunhui Wu, Zhen Wang, Bin Ye, Xiangrui Jiang, Qingjie Zhao, JianfengLi, Yongjian Liu, Junchi Zhang, Guanghui Tian, Yang He, Jingshan Shen, Hualiang Jiang

Study of TRP Channels by Automated Patch Clamp Systems

Author(s): Morten Sunesen, Rasmus B Jacobsen

Structure-based identification of novel KNa1.1 inhibitors

Author(s): Bethan A. Cole, Rachel M. Johnson, Hattapark Dejakaisaya, Stephen P. Muench, & Jonathan D. Lippiat

Structure- and Ligand-Based Discovery of Chromane Arylsulfonamide Nav1.7 Inhibitors for the Treatment of Chronic Pain

Author(s): Steven J. McKerrall, Teresa Nguyen, Kwong Wah Lai, Philippe Bergeron, Lunbin Deng, Antonio Di Pasquale, Jae H. Chang, Jun Chen, Tania Chernov-Rogan, David H. Hackos, Jonathan Maher, Daniel F. Ortwine, Jodie Pang, Jian Payandeh, William R. Proctor, Shannon D. Shields, Jennifer Vogt, Pengfei Ji, Wenfeng Liu, Elisa Ballini, Lilia Schumann, Glauco Tarozzo, Girish Bankar, Sultan Chowdhury, Abid Hasan, J. P. Johnson Jr., Kuldip Khakh, Sophia Lin, Charles J. Cohen, Christoph M. Dehnhardt, Brian S. Safina, Daniel P. Sutherlin

Structural optimization of aminopyrimidine-based CXCR4 antagonists

Author(s): Fang Zhu, Yujie Wang, Qian Du, Wenxiang Ge, Zhanhui Li, Xu Wang, Chunyan Fu, Lusong Luo, Sheng Tian, Haikuo Ma, Jiyue Zheng, Yi Zhang, Xiaotian Sun, Sudan He, Xiaohu Zhang

Strategies for enhancing throughput in ion channel drug screening

Author(s): Rasmus B. Jacobsen, Naja M. Sørensen, Hervør L. Olsen, M. Sunesen, *Niels J. Willumsen

Stable Vhalf values and reliable potentiation of Kv7.3/7.2 currents on Qube 384

Author(s): Melanie Schupp

Stable response for ligand and voltage-gated ion channels on QPatch

Author(s): Hervør Lykke Olsen

Sophion analyzer as a tool for biophysical and pharmacological characterization of eight Nav subtypes evaluated in parallel on Qube

Author(s): Mads P. G. Korsgaard, Lars Damgaard Løjkner, Anders Lindqvist, Mette T Christensen, Thomas Binzer

Simultaneous Measurement of Cardiac Nav1.5 Peak and Late Currents in an Automated QPatch Platform

Author(s): Donglin Guo, Sunny Sun and Stephen Jenkinson

Simultaneous Measurement of Cardiac hERG and Nav1.5 Currents Using an Automated Qube® Patch Clamp Platform

Author(s): Donglin Guo, Tiffany Lee, Daniel Sauter and Stephen Jenkinson

Simultaneous assessment of compound activity on cardiac Nav1.5 peak and late currents in an automated patch clamp platform

Journal: Journal of Pharmacological and Toxicological Methods
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Author(s): Donglin Guo & Stephen Jenkinson

Simple and Effective Generation of Cell-based Assays for Ion Channels, Transporters, and Kinase Screening in Biologically Relevant Cells Using Scalable Transient Transfection

Author(s): Qin (Ching) Chen, James Brady, Karen Donato, Meg Duskin, and Madhusudan Peshwa

Selective Nav1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain

Author(s): Girish Bankar, Samuel J. Goodchild, Sarah Howard, Karen Nelkenbrecher, Matthew Waldbrook, Michelle Dourado, Noah G. Shuart, Sophia Lin, Clint Young, Zhiwei Xie, Kuldip Khakh, Elaine Chang, Luis E. Sojo, Andrea Lindgren, Sultan Chowdhury, Shannon Decker, Michael Grimwood, Jean-Christophe Andrez, Christoph M. Dehnhardt, Jodie Pang, Jae H. Chang, Brian S. Safina, Daniel P. Sutherlin, James P. Johnson, Jr., David H. Hackos, C. Lee Robinette, and Charles J. Cohen

Screening system for drug-induced arrhythmogenic risk combining a patch clamp and heart simulator

Author(s): Jun-ichi Okada1,2,*, Takashi Yoshinaga3, Junko Kurokawa4, Takumi Washio1,2, Tetsushi Furukawa4, Kohei Sawada3, Seiryo Sugiura1,2 and Toshiaki Hisada1,2

Screening strategies for the discovery of ion channel monoclonal antibodies

Author(s): Caroline S. Colley, Elizabeth England, John E. Linley, Trevor C. I. Wilkinson

Screening assay protocols targeting the Nav1.7 Channel using Qube, a high-throughput automated patch clamp system

Author(s): Binbin Qian, Sung H Park, Weifeng Yu

Scaffolds within scaffolds: Generating ion channel blocking antibodies by fusing knottin to peripheral CDR loops

Author(s): A.Karatt-Vellatt1, S. Surade1, D. C. Bell1, T. Leutkens1, E. Masters1, A.M. Luther1, N.M. Sørensen2, N. Butt1 & J. McCafferty1

Scaffold Hopping Toward Agomelatine: Novel 3, 4-Dihydroisoquinoline Compounds as Potential Antidepressant Agents

Author(s): Yang Yang, Wei Ang, Haiyue Long, Ying Chang, Zicheng Li, Liangxue Zhou, Tao Yang, Yong Deng & Youfu Luo

Role of High-Throughput Electrophysiology in Drug Discovery

Author(s): Chang Liu, Tianbo Li, and Jun Chen

Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr–/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator

Author(s): Brandon S. Martin 1), Gabriel Martinez-Botella 2), Carlos M. Loya 2), Francesco G. Salituro 2), Albert J. Robichaud 2), Molly M. Huntsman 3), Mike A. Ackley 2), James J. Doherty 2),* and Joshua G. Corbin 1)

Reliable Kv2.1 assasy and pharmacology on the QPatch


RD(TE671)-nAChR a1 on QPatch

Author(s): Jensen et al, 2010

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target Nav1.7

Author(s): Julie K Klint, Yanni K. Y. Chin, and Mehdi Mobli

Rapid generation of cells for ion channels assays: Efficient, large scale transfection using the MaxCyte STX

Author(s): James Brady, Peer Heine, Rama Shivakumar, Angelia Viley, Madhusudan Peshwa, Karen Donato and Krista Steger - MaxCyte Mark Rothenberg. Corning Inc., Kennebunk, ME, USA. Hervør Lykke Olsen, Nikolaj Nielsen, Kristina Christensen, Jeffrey Webber and Morten Sunesen - Sophion Bioscience

Qube Opto 384 – Optical modulation of ion channels

Author(s): Kim Boddum, Sandra Wilson

Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip

Author(s): Melanie Schupp, Anders Lindqvist, Pia Bladsgaard Andersen, Weifeng Yu

Qube 384-channel patch clamp characterization of the liquid flow channels

Author(s): Rasmus B Jacobsen, Søren Friis, Hervør L Olsen, Mette T Christensen, Kristina M Christensen, Peder S Pedersen, Anders Hyldgaard, Morten Sunesen, Anders Lindqvist

Qube 384 channel patch clamp screening system ligand gated ion channel applications

Author(s): Søren Friis, Rasmus B Jacobsen, Hervør Lykke Olsen, Mette T Christensen, Kristina M. Christensen, Peder Skafte Pedersen, Lasse Homann, Morten Sunesen, Anders Lindqvist

QPatch: the past, present and future of automated patch clamp

Author(s): Chris Mathes

QPatch: the missing link between HTS and ion channel drug discovery.

Journal: Combinatorial Chemistry & High Throughput Screening
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Author(s): Chris Mathes*,1, Søren Friis 2, Michael Finley 3 and Yi Liu 3

Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers

Author(s): Lubos Remen†, Olivier Bezençon*†, Lloyd Simons‡, Rick Gaston‡, Dennis Downing‡, John Gatfield†, Catherine Roch†, Melanie Kessler†, Johannes Mosbacher†, Thomas Pfeifer†, Corinna Grisostomi†, Markus Rey†, Eric A. Ertel†, and Richard Moon†

Predicting Cardiac Proarrhythmic Risk Exclusively Using Automated Patch Clamp Data

Author(s): Edward SA Humphries, John Ridley, Robert Kirby and Marc Rogers

Positive allosteric modulators of α7 nicotinic acetylcholine receptors affect neither the function of other ligand- and voltage-gated ion channels and acetylcholinesterase, nor β-amyloid content

Journal: The International Journal of Biochemistry & Cell Biology
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Author(s): Hugo R. Ariasa, Federica Ravazzinib, Katarzyna M. Targowska-Dudac, Agnieszka A. Kaczord, e, Dominik Feuerbachf, Juan C. Boffig, Piotr Draczkowskid, Dirk Montagh, Brandon M. Browni, Ana Belén Elgoyheng, Krzysztof Jozwiakc, Giulia Puiab

Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels

Author(s): D. Daly a), A. Al-Sabi b), G. K. Kinsella c), K. Nolan a) and J. O. Dolly b)

Physiological modulators of Kv3.1 channels adjust firing patterns of auditory brainstem neurons

Author(s): Maile Reed Brown 1), Lynda El-Hassar 1), Yalan Zhang 1), Giuseppe Alvaro 2), Charles H Large 2), and Leonard K. Kaczmarek 3)

Pharmacological screening technologies for venom peptide discovery

Author(s): Prashanth JR(1, Hasaballah N(1, Vetter I(2

Pharmacological evaluation of GABAA receptor subtypes on Qube 384

Author(s): Kim Boddum, Mads P G Korsgaard

Pharmacological characterization of voltage- and ligand-gated ion channels

Author(s): Hervør L Olsen, Rasmus B Jacobsen, Søren Friis, Morten Sunesen, Niels Willumsen, Rikke Schrøder, Naja M Sørensen, M Knirke Jensen

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

Author(s): Jennifer R. Deuis, Zoltan Dekan, Joshua S. Wingerd, Jennifer J. Smith, Nehan R. Munasinghe, Rebecca F. Bhola 2), Wendy L. Imlach, Volker Herzig, David A. Armstrong, K. Johan Rosengren, Frank Bosmans, Stephen G. Waxman, Sulayman D. Dib-Hajj, Pierre Escoubas, Michael S. Minett, Macdonald J. Christie, Glenn F. King, Paul F. Alewood, Richard J. Lewis, John N. Wood & Irina Vetter

pH-dependent inhibition of K2P3.1 prolongs atrial refractoriness in whole hearts

Author(s): Mark A. Skarsfeldt, Thomas A. Jepps, Sofia H. Bomholtz, Lea Abildgaard, Ulrik S. Sørensen, Emilie Gregers, Jesper H. Svendsen

Personalized medicine: Vinpocetine to reverse effects of GABRB3 mutation

Author(s): Santoshi Billakota, J. Michael Andresen, Bryant C. Gay, Gregory R. Stewart, Nikolai B. Fedorov, Aaron C. Gerlach, Orrin Devinsky

Perforated patch clamp recordings on Qube 384

Author(s): Kadla R. Rosholm

Patch clamping by numbers

Author(s): Claire Wood 1, Gareth J. Waldron* 1, Christine Williams 2, Gareth J. Waldron 2

Patch clamp electrophysiology steps up a gear

Author(s): Derek J. Trezise

Parallel patch clamp of alpha 7 nicotinic acetylcholine receptor channels

Author(s): Søren Friis, Morten Sunesen, Chris Mathes, Mark Bowlby, John Dunlop, Niels Willumsen

Optimizing CHO hERG for automated patch clamping

Author(s): Søren Friis, Hervør L Olsen, Jeffrey Webber, M Knirke Jensen, Dorthe Nielsen, Morten Sunesen, Chris Mathes

Optimization of Cardiac CiPA Targets (hCav1.2 and hKCNQ1/hminK) on the QPatch HT Automated System

Author(s): Bryan Koci, Muthukrishnan Renganathan, Andi Cook, Haiyang Wei, Diane Werth

Optical modulation of ion channels using Qube Opto

Author(s): Kim Boddum, Peder Skafte-Pedersen, Jens Henneke, Daniel Sauter, Jean Francois Rolland, Jiaye Zhang, Sandra Wilson

Optical modulation of ion channels

Author(s): Kim Boddum, Peder Skafte-Pedersen, Jens Henneke, Daniel Sauter, Jiaye Zhang, Sandra Wilson

NS19504: a novel BK channel activator with relaxing effect on bladder smooth muscle spontaneous phasic contractions

Author(s): Nausch B, Rode F, Jørgensen S, Nardi A, Korsgaard MP, Hougaard C, Bonev AD, Brown WD, Dyhring T, Strøbæk D, Olesen SP, Christophersen P, Grunnet M, Nelson MT, Rønn LC.

Novel first-in-class voltage-gated calcium channel positive allosteric modulators that stabilize the open state of the channel and have therapeutic potential to treat a variety of neuromuscular conditions

Author(s): Stephen D. Meriney, Peter Wipf, Kristine Ojala, Stephanie Aldrich, Man Wu, Tyler Tarr, Scott Ginebaugh, Mary Liang, Rozita Laghaei, Mary Cheng, Ivet Bahar, Jon Johnson

Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis

Author(s): Pragnya Das, Santosh K. Panda, Beamon Agarwal, Sumita Behera, Syed M. Ali, Mark E. Pulse, Joseph S. Solomkin, Steven M. Opal, Vineet Bhandari & Suchismita Acharya

NMDA Receptor Modulators in QPatch

Author(s): Ezio Bettini, Laura Aldegheri, Laura Castelletti, Mauro Corsi and Caterina Virginio

NIH 3T3 CFTR on QPatch

Author(s): Jacobsen et al, 2012

New positive Ca2+-activated K+ channel gating modulators with selectivity for KCa3.1

Author(s): Nichole Coleman, Brandon M. Brown, Aida Oliván-Viguera, Vikrant Singh, Marilyn M. Olmstead, Marta Sofia Valero, Ralf Köhler and Heike Wulff

New CiPA cardiac ion channel cell lines and assays for in vitro proarrhythmia risk assessment

Author(s): Edward SA Humphries, Robert W. Kirby, Louise Webdale and Marc Rogers

New CiPA cardiac ion channel cell lines and assays for in vitro proarrhythmia risk assessment

Journal: Poster at Japanese Safety Pharmacology Society, Annual Meeting
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Author(s): Edward HUMPHRIES, Robert KIRBY, John Ridley, Hironori OHSHIRO, and Marc ROGERS

Nav1.5(Late) cardiac safety assay on QPatch

Author(s): Edward S A Humphries

Nav1.5 use-dependent blockers on QPatch X

Author(s): Rasmus B Jacobsen, M Knirke Jensen

NaV1.5 big late : An inactivation deficient mutant of NaV1.5 as screening tool for late sodium currents of the cardiac action potential

Author(s): Camille Bouyer, Simon Hebeisen

Nav1.1 currents on Qube

Author(s): Julie Klint, Melanie Schupp

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Author(s): Marco C. Inserra, Mathilde R. Israel, Ashlee Caldwell, Joel Castro, Jennifer R. Deuis, Andrea M. Harrington, Angelo Keramidas, Sonia Garcia-Caraballo, Jessica Maddern, Andelain Erickson, Luke Grundy, Grigori Y. Rychkov, Katharina Zimmermann, Richard J. Lewis, Stuart M. Brierley & Irina Vetter

Multi-parameter ion channel screening: mechanism-of-action data directly from HTS

Author(s): Juha Kammonen, Anthony Lawrence and Jonathan Mann

Modulation of P2X3 and P2X2/3 Receptors by Monoclonal Antibodies

Author(s): Anatoly Shcherbatko‡12, Davide Foletti‡1, Kris Poulsen‡1, Pavel Strop‡, Guoyun Zhu‡, Adela Hasa-Moreno‡, Jody Melton Witt‡, Carole Loo‡, Stellanie Krimm‡, Ariel Pios‡, Jessica Yu‡, Colleen Brown‡, John K. Lee§, Robert Stroud¶, Arvind Rajpal‡ and David Shelton‡

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

Author(s): James Kramer 1*, Carlos A. Obejero-Paz 1*, Glenn Myatt 2, Yuri A. Kuryshev 1, Andrew Bruening-Wright 1, Joseph S. Verducci 3 & Arthur M. Brown 1

Mashiningan improves opioid-induced constipation in rats by activating cystic fibrosis transmembrane conductance regulator chloride channel

Journal: Journal of Pharmacology and Experimental Therapeutics
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Author(s): Yumi Harada, Seiichi Iizuka, Yayoi Saegusa, Sachiko Mogami, Naoki Fujitsuka and Tomohisa Hattori

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype

Author(s): Akello J. Agwa, Poanna Tran, Alexander Mueller, Hue N. T. Tran, Jennifer R. Deuis, Mathilde R. Israel, Kirsten L. McMahon, David J. Craik, Irina Vetter and Christina I. Schroeder

Ligand-activation of GABAA receptors on the automated patch clamp platforms QPatch and Qube 384 using conventional electrophysiology and optopharmacology

Author(s): Melanie Schupp, Kim Boddum, Daniel R. Sauter, Peder Skafte-Pedersen, Linda Blomster, Hervør L. Olsen, Rasmus. B. Jacobsen

Ligand gated ion channels: GABAA receptor pharmacology on QPatch

Author(s): Kim Boddum

Isoindolinone compounds active as Kv1.5 blockers identified using a multicomponent reaction approach

Journal: Bioorganic & Medicinal Chemistry Letters
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Author(s): Johan Kajanus, Ingemar Jacobson, Annika Åstrand (b., Roine I. Olsson, Ulrik Gran, Annika Björe, Ola Fjellström (a., Öjvind Davidsson, Hans Emtenäs, Anders Dahlén, Boel Löfberg, Zhong-Qing Yuan, Johan Sundell, Johan Cassel, Jonna Gyll, Tommy Iliefski, Ågot Högberg, Emma Lindhardt, Jesper Malmberg

Ion channel screening technologies today

Author(s): Georg C. Terstappen

Intracellular Calcium Mobilization in Response to Ion Channel Regulators via a Calcium-Induced Calcium Release Mechanism

Journal: The Journal of Pharmacology and Experimental Therapeutics
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Author(s): Terry Petrou, Hervør L. Olsen, Christopher Thrasivoulou, John R. Masters, Jonathan F. Ashmore, and Aamir Ahmed

Internal solution exchange on Qube

Author(s): D. Sauter

Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Author(s): M. Flinspach, Q. Xu, A. D. Piekarz, R. Fellows, R. Hagan, A. Gibbs, Y. Liu, R. A. Neff, J. Freedman, W. A. Eckert, M. Zhou, R. Bonesteel, M. W. Pennington, K. A. Eddinger, T. L. Yaksh, M. Hunter, R. V. Swanson & A. D. Wickenden

Inhibitory effects of cannabidiol on voltage-dependent sodium currents

Author(s): Mohammad-Reza Ghovanloo, Noah Gregory Shuart, Janette Mezeyova, Richard A Dean, Peter C Ruben and Samuel J Goodchild

Inhibition of the potassium channel KCa3.1 by senicapoc reverses tactile allodynia in rats with peripheral nerve injury

Journal: Volume 795, 15 January 2017, Pages 1–7
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Author(s): Roland G.W. Staala, Tanzilya Khayrullinaa, Hong Zhanga, Scott Davisb, Shaun M. Fallona, Manuel Cajinac, Megan E. Nattinic, Andrew Hub, Hua Zhouc, Suresh Babu Podac, Stevin Zorna, Gamini Chandrasenac, Elena Dalea, Brian Campbella, Lars Christian Biilmann Rønnd, Gordon Munrod, Thomas Mӧllera

In vitro inflammatory knee pain: Of Mice and Men

Author(s): Sampurna Chakrabarti, Luke A. Pattison, Kaajal Singhal, Jolanta Mil, David C Bulmer, Deepak R Jadon, Ewan St. John Smith

Identification of Selective Inhibitors of the Potassium Channel Kv1.1–1.2(3) by High-Throughput Virtual Screening and Automated Patch Clamp

Author(s): Sören J. Wacker, Dr. Wiktor Jurkowski, Dr. Katie J. Simmons, Prof. Dr. Colin W. G. Fishwick, Prof. Dr. A. Peter Johnson, Dr. David Madge, Prof. Dr. Erik Lindahl, Dr. Jean‐Francois Rolland, Prof. Dr. Bert L. de Groot

Identification of Quinoline-Based RIP2 Kinase Inhibitors with an Improved Therapeutic Index to the hERG Ion Channel

Author(s): Pamela A. Haile, Linda N. Casillas, Michael J. Bury, John F. Mehlmann, Robert Singhaus, Jr., Adam K. Charnley, Terry V. Hughes, Michael P. DeMartino, Gren Z. Wang, Joseph J. Romano, Xiaoyang Dong, Nikolay V. Plotnikov, Ami S. Lakdawala, Maire A. Convery, Bartholomew J. Votta, David B. Lipshutz, Biva M. Desai, Barbara Swift, Carol A. Capriotti, Scott B. Berger, Mukesh K. Mahajan, Michael A. Reilly, Elizabeth J. Rivera, Helen H. Sun, Rakesh Nagilla, Carol LePage, Michael T. Ouellette, Rachel D. Totoritis, Brian T. Donovan, Barry S. Brown†, Khuram W. Chaudhary†, Peter J. Gough, John Bertin, and Robert W. Marquis

Identification of novel activators of two-pore domain potassium (K2P) channels

Author(s): David McCoull, Lewis Byrom, Jonathan Large, Jeff Jerman, Paul D Wright

Identification and Electrophysiological Evaluation of 2-Methylbenzamide Derivatives as Nav1.1 Modulators

Author(s): François Crestey§, Kristen Frederiksen§, Henrik S. Jensen§, Kim Dekermendjian§, Peter H. Larsen§, Jesper F. Bastlund§, Dunguo Lu†, Henry Liu†, Charles R. Yang†, Morten Grunnet*§, and Niels Svenstrup*§

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

Author(s): Fernanda C. Cardoso, Zoltan Dekan, K. Johan Rosengren, Andelain Erickson, Irina Vetter, Jennifer R. Deuis, Volker Herzig, Paul F. Alewood, Glenn F. King, and Richard J. Lewis

Icrac measurement on QPatch

Author(s): M Knirke Jensen, Rikke Perrier Schrøder, Hervor Lykke Olsen

Human iPS cell-derived cardiomyocytes (Cor.4U®) on Sophion’s Qube 384: Voltage and current clamp recordings

Author(s): Daniel Sauter

HT Automation for patch clamp based primary screen for Nav1.1 using Qube 384

Author(s): Julie K. Klint, Melanie Schupp, Daniel R P Sauter, Rasmus Jacobsen, Thomas Binzer

High-Throughput Screening of Nav1.7 Modulators Using a Giga-Seal Automated Patch Clamp Instrument

Author(s): Chris Chambers, Ian Witton, Cathryn Adams, Luke Marrington and Juha Kammonen

High-throughput screening of induced pluripotent stem cell-derived motor neurons on Qube and QPatch

Author(s): Kadla Røskva Rosholm, Daniel Sauter, Melanie Schupp, Rasmus B Jacobsen

High-Throughput Screen of GluK1 Receptor Identifies Selective Inhibitors with a Variety of Kinetic Profiles Using Fluorescence and Electrophysiology Assays

Author(s): Kelli Solly 1), Rebecca Klein 2), Michael Rudd 3), M. Katharine Holloway 4), Eric N. Johnson 1),*, Darrell Henze 2), Michael F. A. Finley 1)

High-throughput electrophysiology: An emerging paradigm for ion-channel screening and physiology

Author(s): John Dunlop, Mark Bowlby, Ravikumar Peri, Dmytro Vasilyev & Robert Arias

High throughput screening for mode-of-action on Nav1.7

Author(s): Daniel Sauter

High throughput screening for mode-of-action on Nav1.4

Author(s): Daniel Sauter

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development

Journal: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
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Author(s): Juan C. del Álamo a), Derek Lemonsb, c), Ricardo Serrano a), Alex Savchenkob, c, e), Fabio Cerignoli d), Rolf Bodmer c), Mark Mercolab, c, e)

High Throughput Electrophysiology: New Perspectives for Ion Channel Drug Discovery

Author(s): Niels J. Willumsen, Morten Bech, Søren-Peter Olesen, Bo Skaaning Jensen, Mads P. G. Korsgaard, and Palle Christophersen

Hesperetin preferentially inhibits slow-activating currents of an LQT3 syndrome Na+ channel mutation

Author(s): Julio Alvarez-Collazo, Alejandro López-Requena, Loipa Galán, Ariel Talavera, Julio L. Alvarez and Karel Talavera

HEK293-TRPV1 on QPatch

Author(s): Rasmus B Jacobsen, Knirke M Jensen

HEK293-KCa on QPatch

Author(s): Rasmus B Jacobsen, M Knirke Jensen

HEK-hKir2.1 on QPatch

Author(s): Hervor Lykke Olsen, Morten Sunesen,

HEK-Cav3.2 recordings on QPatch

Author(s): Jensen et al., 2012

hCav1.2 recordings using QPatch

Author(s): Kadla R Rosholm, Melanie Schupp

hCav1.2 recordings on Qube 384 using step, train and CiPA protocols

Author(s): Melanie Schupp, Kadla R Rosholm

GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability

Author(s): Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A

GH4-C1 nAChR a7 on QPatch

Author(s): M Knirke Jensen, Søren Friis

Generating potent and selective inhibitors of Kv1.3 ion channels by fusing venom derived mini proteins into peripheral CDR loops of antibodies

Author(s): Lien Moreels, A. Karatt-Vellatt, D. C. Bell, S. Surade, P. A. Slavny, T. Luetkens, E. Masters & J. McCafferty

GABAA receptor pharmacology evaluted in overexpressing HEK cells and primary astrocytes on QPatch

Author(s): Kim Boddum, Kadla Røskva Rosholm, Linda Blomster, Hervør Lykke Olsen, Naja Møller Sørensen, Göran Mattsson

GABA-A receptor pharmacology evaluated in overexpressing HEK cells and primary astrocytes on QPatch

Author(s): Kim Boddum1, Kadla Røskva Rosholm1, Linda Blomster2, Hervør Lykke Olsen, Naja Møller Sørensen1, Göran Mattsson1

GABA-A a17B3y2 on QPatch

Author(s): Hervor L Olsen, M Knirke Jensen

Functional Studies of Sodium Channels: From Target to Compound Identification

Journal: Wiley Online Library DOI: 10.1002/cpph.14
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Author(s): Daniel Bertrand 1), Bruno Biton 2), Thomas Licher 3), Jean-Marie Chambard 2), Christophe Lanneau 2), Michel Partiseti 2), Isabel A. Lefevre 2)

Functional Assessment of hNav1.x Ion Channels Using State- Dependent Protocols on the QPatch HT Automated Patch Clamp System

Author(s): Bryan Koci, Jennifer Wesley, Muthukrishnan Renganathan, Haiyang Wei, Diane Werth

From identification to functional characterization of cyriotoxin-1a, an antinociceptive toxin from the spider Cyriopagopus schioedtei.

Author(s): Gonçalves TC, Benoit E, Kurz M, Lucarain L, Fouconnier S, Combemale S, Jaquillard L, Schombert B, Chambard JM, Boukaiba R, Hessler G, Bohme A, Bialy L, Hourcade S, Béroud R, De Waard M, Servent D, Partiseti M

Fast series resistance compensation on Qube 384 and QPatch

Author(s): Jacobsen et al., 2016

Fast desensitizing ion channels recorded on Qube 384

Author(s): Daniel Sauter et Al.

Extracellular K+ Dampens T Cell Functions: Implications for Immune Suppression in the Tumor Microenvironment

Author(s): Seow Theng Ong, Aik Seng Ng, Xuan Rui Ng, Zhong Zhuang, Brandon Han Siang Wong, Praseetha Prasannan, Yee Jiun Kok, Xuezhi Bi, Heesung Shim, Heike Wulff, Kanianthara George Chandy, and Navin Kumar Verma

Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques

Author(s): Rikke P Schrøder, Mette T Christensen, Blake Anson, Morten Sunesen

Evaluation of throughput and data quality

Author(s): Hervor L Olsen, Rikke P Schrøder, Rasmus B Jacobsen, Søren Friis, Morten Sunesen

Estimating hERG drug binding using temperature-controlled high throughput automated patch clamp

Author(s): Anders Lindqvist, Mette T Christensen

Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel Nav1.7 Inhibition

Author(s): Hue N. T. Tran, Poanna Tran, Jennifer R. Deuis, Akello J. Agwa, Alan H. Zhang, Irina Vetter and Christina I. Schroeder

Enhancing throughput with multiple cell lines per well with the QPatch HTX

Author(s): Hervor L Olsen, Rikke P Schrøder

Enhancing throughput with multiple cell lines per well

Author(s): Hervor L Olsen, Dorthe Nielsen, Morten Sunesen

Engineering Highly Potent and Selective Microproteins Against Nav1.7 Sodium Channel for Treatment of Pain

Author(s): Anatoly Shcherbatko1, Andrea Rossi1, Davide Foletti2, Guoyun Zhu1, Oren Bogin3, Meritxell Galindo-Casas1, Mathias Rickert4, Adela Hasa-Moreno1, Victor Bartevitch5, Andreas Crameri6, Alexander R. Steiner7, Robert Henningsen7, Avinash Gill8, Jaume Pons1, David L. Shelton1, Arvind Rajpal9 and Pavel Strop1*

Endogenous Ion Channels of Mammalian Cell Lines Characterization

Author(s): Søren Friis, Rasmus B Jacobsen, Morten Sunesen, Dorthe Nielsen, Nadia Larsen, Chris Mathes, Niels Willumsen

Electrophysiological properties of iCell cardiomyocytes obtained by automated patch clamp

Author(s): Rikke P Schrøder 1), Mette T Christensen 1), Giorgia Salvagiotto 2), Blake Anson 2), Morten Sunesen 1)

Electrophysiological characterization of human iPSC-derived motor neurons using Qube 384 and QPatch

Author(s): Kadla R Rosholm

Electrophysiological characterization of human induced pluripotent stem cell-derived dopaminergic neurons using manual and automated patch clamp systems

Author(s): Denise Franz, Jan Giemsa, Oliver Klink, Hervør Lykke Olsen

Electrophysiological characterization of human dopaminergic neurons derived from LUHMES cells

Author(s): Udo Kraushaar, Dominik Loser, Timm Danker, Clemens Möller, Marcel Leist

Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform

Author(s): Camille Sanson, Brigitte Schombert, Bruno Filoche-Romme, Michel Partiseti and G. Andrees Bohme

Eleclazine exhibits enhanced selectivity for long QT syndrome type 3–associated late Na+ current

Author(s): Nesrine El-Bizri, Cheng Xie, Lynda Liu, James Limberis, Michael Krause, Ryoko Hirakawa, Steven Nguyen, Dennis R. Tabuena, Luiz Belardinelli, Kristopher M.Kahlig

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7

Author(s): Agwa AJ, Blomster LV, Craik DJ, King GF, Schroeder CI.

Effect of antiarrhythmic drugs on small conductance calcium – activated potassium channels

Author(s): Rafel Simó-Vicensa, Daniel R.P. Sauter, Morten Grunnet, Jonas G. Diness, Bo H. Bentzen

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

Author(s): Ana Guardia, Jessica Baiget, Mónica Cacho, Arancha Pérez, Montserrat Ortega-Guerra, Winston Nxumalo, Setshaba D. Khanye, Joaquín Rullas, Fátima Ortega, Elena Jiménez, Esther Pérez-Herrán, María Teresa Fraile-Gabaldón, Jorge Esquivias, Raquel Fernández, Esther Porras-De Francisco, Lourdes Encinas, Marta Alonso, Ilaria Giordano, Cristina Rivero, Juan Miguel-Siles, Javier G. Osende, Katrina A. Badiola, Peter J. Rutledge , Matthew H. Todd, Modesto Remuiñán, and Carlos Alemparte

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide are Potent TMEM16A Antagonists that Fully Bronchodilate Airway

Author(s): Kent Miner, Katja Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, Robin Elliott, Jian Jeffrey Chen, Longbin Liu, Anh Leith, Esther Trueblood, Kelly Hensley, Xing-Zhong Xia, Oliver Homann, Brian Bennett, Mike Fiorino, John Whoriskey, Gang Yu, Sabine Escobar, Min Wong, Teresa L. Born, Alison Budelsky, Mike Comeau, Dirk Smith, Jonathan Phillips, James A. Johnston, Joe McGivern, Kerstin Weikl, David Powers, Karl Kunzelmann, Deanna Mohn, Andreas Hochheimer, John K. Sullivan

Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination

Author(s): Bandita Bagchi, Ahmed Al-Sabi, Seshu Kaza, Dimitri Scholz, Valerie B. O’Leary, J. Oliver Dolly, Saak V. Ovsepian

Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination

Author(s): Bandita Bagchi, Ahmed Al-Sabi, Seshu Kaza, Dimitri Scholz, Valerie B. O'Leary, J. Oliver Dolly , Saak V. Ovsepian

Discovery of Dihydrobenzoxazepinone (GS-6615) Late Sodium Current Inhibitor (Late INai), a Phase II Agent with Demonstrated Preclinical Anti-Ischemic and Antiarrhythmic Properties

Author(s): Jeff A. Zablocki*†, Elfatih Elzein†, Xiaofen Li†, Dmitry O. Koltun†, Eric Q. Parkhill†, Tetsuya Kobayashi†, Ruben Martinez†, Britton Corkey†, Haibo Jiang†, Thao Perry†, Rao Kalla†, Gregory T. Notte†, Oliver Saunders†, Michael Graupe†, Yafan Lu†, Chandru Venkataramani†, Juan Guerrero†, Jason Perry⊥, Mark Osier§, Robert Strickley∥,Gongxin Liu#, Wei-Qun Wang#, Lufei Hu#, Xiao-Jun Li#, Nesrine El-Bizri#, Ryoko Hirakawa#, Kris Kahlig#, Cheng Xie#, Cindy Hong Li#, Arvinder K. Dhalla#, Sridharan Rajamani#, Nevena Mollova‡, Daniel Soohoo‡, Eve-Irene Lepist‡, Bernard Murray‡, Gerry Rhodes‡, Luiz Belardinelli#, and Manoj C. Desai†

Discovery of (S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.

Author(s): Panayiotis A. Procopiou , Niall A. Anderson, John Barrett, Tim N. Barrett, Matthew H. J. Crawford, Brendan J. Fallon, Ashley P. Hancock, Joelle Le, Seble Lemma, Richard P. Marshall, Josie Morrell, John M. Pritchard, James E. Rowedder, Paula Saklatvala, Robert J. Slack, Steven L. Sollis, Colin J. Suckling, Lee R. Thorp, Giovanni Vitulli, and Simon J. F. Macdonald

Discovery and optimization of a novel series of pyrazolyltetrahydropyran N-type calcium channel (Cav 2.2) blockers for the treatment of pain

Journal: Bioorganic & Medicinal Chemistry Letters
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Author(s): Mark J.Wall, Nalin L.Subasinghe, Michael P.Winters. Mary Lou Lubin, Michael F.A. Finley, Ning Qin Michael, R. Brandt, Michael P.Neeper, Craig R. Schneider, Raymond W.Colburn, Christopher M. Flores, Zhihua Sui

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Author(s): Silmara R. Sousa, Joshua S. Wingerd, Andreas Brust, Christopher Bladen, Lotten Ragnarsson, Volker Herzig, Jennifer R. Deuis, Sebastien Dutertre, Irina Vetter, Gerald W. Zamponi, Glenn F. King, Paul F. Alewood, Richard J. Lewis

Discovery and electrophysiological characterization of SKF-32802; a novel hERG agonist found through a large-scale structural similarity search

Author(s): Brian T. Donovan, Deepak Bandyopadhyay,, Chaya Duraiswami, Christopher J. Nixon, Claire Y. Townsend, Stan F. Martens

Discovery and Characterization of the Potent and Selective P2X4 Inhibitor N-[4-(3-Chlorophenoxy)-3-sulfamoylphenyl]-2-phenylacetamide (BAY-1797) and Structure-Guided Amelioration of Its CYP3A4 Induction Profile

Author(s): Stefan Werner, Stefanie Mesch, Roman C. Hillig , Antonius ter Laak, Julie Klint, Ioana Neagoe, Alexis Laux-Biehlmann, Henrik Dahllöf, Nico Bräuer, Vera Puetter, Reinhard Nubbemeyer, Simone Schulz, Michaela Bairlein, Thomas M. Zollner, Andreas Steinmeyer

Direct evidence for high affinity blockade of NaV1.6 channel subtype by huwentoxin-IV spider peptide, using multiscale functional approaches

Author(s): Tânia C. Gonçalves, Rachid Boukaiba, Jordi Molgób, Muriel Amar, Michel Partiseti, Denis Servent, Evelyne Benoit

Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines

Journal: The Journal of Pharmacology and Experimental Therapeutics
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Author(s): Reyes-Corral M, Sørensen NM, Thrasivoulou C, Dasgupta P, Ashmore JF 1, Ahmed A

Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies

Author(s): Barbara Kaproń, Jarogniew J. Łuszczki, Anita Płazińska, Agata Siwek, Tadeusz Karcz, Anna Gryboś, Gabriel Nowak, Anna Makuch-Kocka, Katarzyna Walczak, Ewa Langner, Karolina Szalast, Sebastian Marciniak, Magdalena Paczkowska, Judyta Cielecka-Piontek, Lukasz M.Ciesla, Tomasz Plech

Development of novel multipotent compounds modulating endocannabinoid and dopaminergic systems

Author(s): Alessandro Grillo, Giulia Chemia Simone Brogi, Margherita Brindisi, Nicola Relitti, Filomena Fezza, Domenico Fazioe, Laura Castelletti, Elisabetta Perdona, Andrea Wong, Stefania Lamponi, Alessandra Pecorelli, Mascia Benedusi, Manuela Fantacci, Massimo Valoti, Giuseppe Valacchihi, Fabrizio Micheli, Ettore Novellino, Giuseppe Campiani Stefania Butini, Mauro Maccarrone, Sandra Gemma

Development of high-throughput electrophysiological assay for the screening of hERG ion channel modulators using Sophion Qube 384

Author(s): David J. Standing, Kelly Gatfield, David L. Downie, Metul Patel, Andrew J. Brown

Development of Automated Patch Clamp Technique to Investigate CFTR Chloride Channel Function

Author(s): Arnaud Billet, Lionel Froux, John W. Hanrahan and Frederic Becq

Development of Automated Patch Clamp Assay for Evaluation of α7 Nicotinic Acetylcholine Receptor Agonists in Automated QPatch 16

Author(s): Hao Yuchen 1), Tang Jingshu 2), and Wang KeWei 3)

Development of an Ultra High-Throughput Screen to Identify Antagonists for GluK1

Author(s): Kelli Solly1 , Carissa Quinn1 , Rebecca Klein2 , Darrel Henze 2 , Eric Johnson1 , and Michael Finley 1

Development of an Automated Patch Clamp Assay for recording STIM1/Orai1 – mediated currents using Qube 384

Author(s): Daniels Sauter, Rasmus Jacobsen

Development of a QPatch Automated Electrophysiology Assay for Identifying KCa3.1 Inhibitors and Activators

Author(s): David Paul Jenkins 1), Weifeng Yu 2), Brandon M. Brown 1), Lars Damgaard Løjkner 2) and Heike Wulff 1)

Development of a novel screening system to identify activators to two-pore domain potassium channels (K2Ps)

Author(s): David McCoull, Emma Ococks, Paul D Wright

Development of a high-throughput fluorescent no-wash sodium influx assay

Author(s): Bryan Tay, Teneale A. Stewart, Felicity M. Davis, Jennifer R. Deuis, Irina Vetter

Development and validation of NMDA ligand-gated ion channel assays using the Qube 384 automated electrophysiology platform

Author(s): Abigail Marklew, Juha Kammonen, Emma Richardson, and Jonathan Mann

Development and validation of ligand-gated ion channel assays using the Qube 384 automated electrophysiology platform

Author(s): Abigail Marklew, Juha Kammonen, Emma Richardson and Gary Clark

Developing Molecular Pharmacology of BK Channels for Therapeutic Benefit

Author(s): G.J. Kaczorowski, M.L. Garcia

Design, synthesis, and biological evaluation of fluorinated imidazo[1,2-a]pyridine derivatives with potential antipsychotic activity

Author(s): Monika Marcinkowska, Marcin Kołaczkowskia, Krzysztof Kamińskia, Adam Buckia, Maciej Pawłowskia, Agata Siweka, Tadeusz Karcza, Barbara Mordyla, Gabriela Starowicza, Paulina Kubowicza, Elżbieta Pękalaa, Anna Wesołowskaa, Jerzy Samochowiecb, Paweł Mierzejewskic, Przemyslaw Bienkowskic

Design, synthesis and biological evaluation of tetrahydronaphthyridine derivatives as bioavailable CDK4/6 inhibitors for cancer therapy

Author(s): Chuantao Zha, Wenjia Deng, Yan Fu, Shuai Tang, Xiaojing Lan, Yan Yea, Yi Su, Lei Jiang, Yi Chen, Ying Huang, Jian Ding, Meiyu Geng, Min Huang, Huixin Wan

Design, synthesis and biological evaluation of 7H-pyrrolo[2,3-d]pyrimidin-4-amine derivatives as selective Btk inhibitors with improved pharmacokinetic properties for the treatment of rheumatoid arthritis

Author(s): Linhong Hea, Heying Peia, Chufeng Zhanga, Mingfeng Shao, Dan Li, Mingli Tang, Taijing Wang, Xiaoxin Chen, Mingli Xiang, Lijuan Chen

Design, synthesis and biological evaluation of 4,7,12,12a-tetrahydro-5H-thieno[3′,2’:3,4]pyrido[1,2-b]isoquinolines as novel adenosine 5′-monophosphate-activated protein kinase (AMPK) indirect activators for the treatment of type 2 diabetes

Author(s): Shengbin Zhou(ab1, Yanan Duan(c1, Jiang Wang(ab1, Jin Zhang(c Haifeng Sun(a,b Haowen Jiang(c, Zhanni Gu(ab, Junhua Tong(ab, Jingya Li(a, Jia Li(a, Hong Liu(ab

Data quality is not affected by cell suspension density

Author(s): Chris Mathes, Hervør L Olsen, Michael Stoltenborg, Morten Sunesen, Niels Willumsen

Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells

Author(s): James Kramer, Herbert M. Himmel, Anders Lindqvist, Sonja Stoelzle-Feix, Khuram W. Chaudhary, Dingzhou Li, Georg Andrees Bohme, Matthew Bridgland-Taylor, Simon Hebeisen, Jingsong Fan, Muthukrishnan Renganathan, John Imredy, Edward S. A. Humphries, Nina Brinkwirth, Tim Strassmaier, Atsushi Ohtsuki, Timm Danker, Carlos Vanoye, Liudmila Polonchuk, Bernard Fermini, Jennifer Beck Pierson & Gary Gintant

Cor.At cells embryonic stem cell derived cardiomyocytes on QPatch

Author(s): Rikke P Schrøder, Hervor L Olsen, M Knirke Jensen

Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative

Journal: Journal of Pharmacological and Toxicological Methods
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Author(s): Takasuna K1, Asakura K2, Araki S3, Ando H4, Kazusa K5, Kitaguchi T6, Kunimatsu T7, Suzuki S8, Miyamoto N9.

Cold potentiates current through mechanosensitive Piezo2 ion channel, but inhibits Piezo1

Author(s): Yury Nikolaev, Wang Zheng, Elena Gracheva, Slav Bagriantsev

Co-expression of β Subunits with the Voltage-Gated Sodium Channel NaV1.7: the Importance of Subunit Association and Phosphorylation and Their Effects on Channel Pharmacology and Biophysics

Author(s): Sokolov MV, Henrich-Noack P, Raynoschek C, Franzén B, Larsson O, Main M, Dabrowski M

Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels

Author(s): Zidar N1, Žula A1, Tomašič T1, Rogers M2, Kirby RW2, Tytgat J3, Peigneur S3, Kikelj D1, Ilaš J4, Mašič LP5

CiPA hERG Milnes kinetic assay on QPatch

Author(s): Edward S A Humphries, Metrion Biosciences Ltd. and Thomas Binzer, Sophion Bioscience A/S

CHO-Nav1.5 on QPatch

Author(s): Hervor L Olsen

CHO-KvLQT1 minK on QPatch

Author(s): Hervor L Olsen, Morten Sunesen

CHO-Kv1.5 Voltage-gated potassium channels on QPatch

Author(s): M Knirke Jensen, Hervor L Olsen, Morten Sunesen

CHO-hNav1.7 assay on Qube pharmacology, biophysical characterization and the effect of internal fluoride

Author(s): Sauter et Al, 2017

CHO-hERG Duo in multi-hole mode on QPatch

Author(s): Rasmus B Jacobsen, Søren Friis, M Knirke Jensen

CHO-hERG Duo characterization and functional validation on QPatch

Author(s): Rasmus B Jacobsen, Søren Friis, M Knirke Jensen

CHO and HEK-TRPM8 tested on QPatch

Author(s): M. Knirke Jensen

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Author(s): Drew C. Tilleya (1, Kenneth S. Euma, (b,1,2, Sebastian Fletcher-Taylora, Daniel C. Austina, Christophe Dupréb, Lilian A. Patrónb, Rita L. Garciac, Kit Lamd, Vladimir Yarov-Yarovoya,d, Bruce E. Cohenc, and Jon T. Sacka,b (3

Characterization of the rapidly-desensitizing α7 nicotinic acetylcholine receptor using the Qube

Author(s): Sung H. Park, Daniel R. Sauter, Weifeng Yu, Lena Bengtsson, Stefanie Makinson, Orion P. Keifer

Characterization of Potassium Channel Modulators with QPatch™ Automated Patch-Clamp Technology: System Characteristics and Performance To cite this article:

Author(s): Jonatan Kutchinsky, Søren Friis, Margit Asmild, Rafael Taboryski, Simon Pedersen, Ras K. Vestergaard, Rasmus B. Jacobsen, Karen Krzywkowski, Rikke L. Schrøder, Trine Ljungstrøm, Nathalie Hélix, Claus B. Sørensen, Morten Bech, and Niels J. Willumsen

Characterization of P2X3 receptors using QPatch

Author(s): Daniel Sauter, Göran Mattsson

Characterization of Human iPSC-derived cardiomyocytes (Cor.4U®) on an automated planar patch clamp set up (Qube)

Author(s): Daniel R. Sauter, Kadla R. Rosholm, Kim Boddum, Kazuya Tsurudome, Rasmus. B. Jacobsen, Göran Mattsson

Characterization of human iPSC-derived cardiomyocytes (Cor.4U) on an automated planar patch clamp set-up (QPatch)

Author(s): Daniel Sauter, Kim Boddum, Kazuya Tsurudome, Rasmus B Jacobsen, Göran Mattsson

Characterization of hiPSC-derived neurological disease models using automated patch clamp (Qube and QPatch)

Author(s): Kadla Røskva Rosholm, Melanie Schupp, Daniel Sauter, Rasmus B Jacobsen

Characterization of hiPSC-derived neurological disease models using automated patch clamp (Qube and QPatch)

Author(s): Kadla Røskva Rosholm, Melanie Schupp, Daniel Sauter, Rasmus B Jacobsen

Characterization of hERG blockers using the automated QPatch 16 screening system

Author(s): Rasmus B Jacobsen, Simon Pedersen, Søren Friis, Nicoline Andersen, Niels Willumsen

Characterization of Endogenous Sodium Channels in the ND7-23 Neuroblastoma Cell Line: Implications for Use as a Heterologous Ion Channel Expression System Suitable for Automated Patch Clamp Screening

Author(s): Marc Rogers 1, Nace Zidar 2 Danijel Kikelj 2 and Robert W. Kirby 1

Characterization of compounds on nicotinic acetylcholine receptor alpha7 channels using higher throughput electrophysiology

Author(s): S. Friis a), C. Mathes a,∗), M. Sunesen a), M.R. Bowlby b), J. Dunlop a)

CFTR channels activated by flouride on QPatch

Author(s): Naja Møller Sørensen et al., 2016

Cell volume and membrane stretch independently control K+ channel activity

Author(s): Sofia Hammami 1,2), Niels J. Willumsen 1), Hervør L. Olsen 3), Francisco J. Morera 4), Ram´on Latorre 4) and Dan A. Klaerke 2)

Cell culturing for automated patch clamp

Author(s): Pia B Andersen, Mette T Christensen

Cav1.2 on Qube 384 – pharmacology, stability and CiPA

Author(s): Melanie Schupp, Rasmus Jacobsen, Mads P G Korsgaard

Cav1.2 on Qube 384

Author(s): Schupp, Melanie

Cardiomyocytes Derived from Human Induced Pluripotent Stem Cells: An In-Vitro Model to Predict Cardiac Effects of Drugs

Journal: Journal of Biomedical Science and Engineering
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Author(s): Romain Sube, Eric A. Ertel

Cardiac sodium channel antagonism – Translation of preclinical in vitro assays to clinical QRS prolongation

Journal: Journal of Pharmacological and Toxicological Methods
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Author(s): Stephen Jenkinson, Asser Bassyouni, Jason Cordes, Bernard Fermini, Donglin Guo, David M.Potter, David S.Ramirez, Jill Steidl-Nichols, Sunny Sun, ToddWisialowski

Cardiac safety assessment with motion field imaging analysis of human iPS cell-derived cardiomyocytes is improved by an integrated evaluation with cardiac ion channel profiling

Author(s): Isobe T, Honda M, Komatsu R, Tabo M

Cancer as a channelopathy: ion channels and pumps in tumor development and progression

Author(s): Alisa Litan and Sigrid A. Langhans

Calcium-activated chloride channel ANO1 promotes breast cancer progression by activating EGFR and CAMK signaling

Author(s): Adrian Britschgia, Anke Billb, Heike Brinkhausa, Christopher Rothwell, Ieuan Clay, Stephan Duss, Michael Rebhan, Pichai Raman, Chantale T. Guy, Kristie Wetzel, Elizabeth George, M. Oana Popa, Sarah Lilley, Hedaythul Choudhury, Martin Gosling, Louis Wang, Stephanie Fitzgerald, Jason Borawski, Jonathan Baffoe, Mark Labow, L. Alex Gaither, and Mohamed Bentires-Al

Biphenyloxy-alkyl-piperidine and azepane derivatives as histamine H3 receptor ligands

Author(s): Dorota Lazewska (a, Maria Kaleta(a, J. Stephan Schwed(b, Tadeusz Karcz(a, Szczepan Mogilski(c, Gniewomir Latacz(a, Agnieszka Olejarz(a, AgataSiwek(d, Monika Kubacka(c, Annamaria Lubelska(a, Ewelina Honkisz(a, Jadwiga Handzlik(a, Barbara Filipek(c, HolgerStark(b, Katarzyna Kieć-Kononowicz(a

Biophysical and pharmacological profiling of multiple voltage-gated sodium channel subtypes on QPatch II

Author(s): Daniel Sauter, Mette T Christensen, Rasmus B Jacobsen, Göran Mattsson

Biophysical and pharmacological profiling of multiple voltage-gated sodium channel subtypes on QPatch II

Author(s): Daniel Sauter, Mette T Christensen, Rasmus B Jacobsen, Göran Mattsson

Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT

Author(s): Anders Lindqvist, Søren Friis, Mette T. Christensen & Mads P.G. Korsgaard

Biophysical and pharmacological characterization of multiple Nav subtypes on Qube

Author(s): Anders Lindqvist, Søren Friis, Mette T. Christensen & Mads P.G. Korsgaard

Biophysical and pharmacological characterization of ligandgated ion channels in multi-hole mode

Author(s): M. Knirke Jensen, Rikke Schrøder, Hervør L. Olsen, Rasmus B. Jacobsen, Jeffrey Webber, Søren Friis, Dorthe Nielsen, Mette T. Christensen, Morten Sunesen

Biological Profiling of Coleoptericins and Coleoptericin-Like Antimicrobial Peptides from the Invasive Harlequin Ladybird Harmonia axyridis

Journal: Advances in Experimental Medicine and Biology
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Author(s): Rolf Hirsch, Jochen Wiesner, Alexander Marker, Armin Bauer, Peter E. Hammann, Andreas Vilcinskas

Benzothiophenes as Potent Analgesics Against Neuropathic Pain

Author(s): Saurabh Yadav, Vishnu Kumar Dwivedi, Sarika Gupta, Avadhesha Surolia

Automation of patch clamp techniques: Technical validation through characterization of voltage-gated potassium channels and ligand-gated ion channels

Author(s): Karen Krzywkowski, Rikke Schrøder, Trine Ljungstrøm, Jonatan Kutchinsky, Søren Friis, Margit Asmild, Rafael Taborski, Simon Pedersen, Ras K. Vestergaard, Rasmus B Jacobsen, Nathalie Helix, Claus B Sørensen Morten Bech, Jeppe K Christensen, Simon du Beau, Niels Willumsen

Automatic estimation of hNaV1.5 channel inactivation improves pharmacological evaluation using the new adaptive protocol feature on Qube

Author(s): Anders Lindqvist

Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Nav, KCa2.3, and Kv11.1 Channels

Journal: Combinatorial Chemistry & High Throughput Screening
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Author(s): Mads P.G. Korsgaard, Dorte Strøbæk and Palle Christophersen

Automated Patch-Clamp Technique: Increased Throughput in Functional Characterization and in Pharmacological Screening of Small-Conductance Ca2+ Release-Activated Ca2+ Channels

Author(s): Rikke L. Schrøder 1), Søren Friis 1), Morten Sunesen 1), Chris Mathes 2), and Niels J. Willumsen 3)

Automated Patch Clamping Using the QPatch

Author(s): Kenneth A. Jones, Nicoletta Garbati, Hong Zhang, and Charles H. Large

Automated High Throughput Na+ Late Current Assay on QPatch HT Platform for CiPA28

Author(s): Muthukrishnan Renganathan, Bryan J. Koci, Andi Cook, Haiyang Wei, Diane Werth

Automated Electrophysiology: High Throughput of Art

Author(s): Xiaobo Wang 1), Min Li 2)

Automated and manual patch clamp data of human induced pluripotent stem cell-derived dopaminergic neurons

Author(s): Denise Franz, Hervør Lykke Olsen, Oliver Klink & Jan Gimsa

Assessing functional properties of ligand-gated ion channels with automated whole-cell patch clamp technology

Author(s): Hervør L Olsen, Rasmus B Jacobsen, Rikke Schrøder, Jonatan Kutchinsky, Morten Sunesen, Niels Willumsen

Arrangement of Kv1 α subunits dictates sensitivity to tetraethylammonium

Author(s): Ahmed Al-Sabi, Oleg Shamotienko, Sorcha Ni Dhochartaigh, Nagesh Muniyappa, Marie Le Berre, Hamdy Shaban, Jiafu Wang, Jon T. Sack, J. Oliver Dolly

Are stem-cell cardiomyocytes a viable cellular reagent for automated patch-clamp?

Author(s): Michael Morton, Lauren Eades

Application of QPatch 16 for drug screening of ligand-gated ion channels

Author(s): Nicoline R. Andersen, Simon Pedersen, Jeppe K. Christensen, Michael Stoltenborg, Morten Sunesen, Niels J. Willumsen

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of Nav1.7-Mediated Pain

Author(s): Jennifer R. Deuis 1,2, Joshua S. Wingerd 1, Zoltan Winter 3, Thomas Durek 1, Zoltan Dekan 1, Silmara R. Sousa 1, Katharina Zimmermann 3, Tali Hoffmann 3, Christian Weidner 3, Mohammed A. Nassar 4, Paul F. Alewood 1, Richard J. Lewis 1 and Irina Vetter 1,2,*

An Official American Thoracic Society Workshop Report: Translational Research in Rare Respiratory Diseases

Author(s): Kristof AS, Petrof BJ, Hamid Q, Kolb M, Landry JS, MacKenzie A, McCormack FX, Murawski IJ, Moss J, Rauch F, Rosas IO, Shapiro AJ, Smith BM, Thomas DY, Trapnell BC, Young LR, Zariwala MA

Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality

Author(s): Christopher R. Butler*† , Kevin Ogilvie§, Luis Martinez-Alsina§, Gabriela Barreiro†, Elizabeth M. Beck†, Charles E. Nolan‡, Kevin Atchison‡, Eric Benvenuti⊥, Leanne Buzon§, Shawn Doran⊥, Cathleen Gonzales‡, Christopher J. Helal§, Xinjun Hou†, Mei-Hui Hsu#, Eric F. Johnson#, Kimberly Lapham⊥, Lorraine Lanyon⊥, Kevin Parris∥, Brian T. O’Neill§, David Riddell‡, Ashley Robshaw‡, Felix Vajdos∥, and Michael A. Brodney†

Adaptive voltage protocols increase precision of voltage-gated ion channel measurements on highthroughput automated patch clamp platforms

Author(s): Sarah Williams & Juha Kammonen

Adaptive voltage control ensures the precise half inactivation application of voltage-gated channels on automated patch clamp system

Author(s): Kazuya Tsurudome, Hironori Ohshiro, Anders Lindqvist, Rasmus B. Jacobsen

Activities for Optimizing CiPA Recommended Protocols in Patch-Clamp Assay

Author(s): Yoshimi KATAYAMA, Hiroshi MATSUKAWA, Tomokazu KANEHISA, Ayane ABE, Takashi YOSHINAGA, Keiichi ASAKURA, Kimihito YOSHIKAWA, Kazuya TSURUDOME, Tadaaki TSUKAMOTO

A systematic strategy for estimating hERG block potency and its implications in a new cardiac safety paradigm

Author(s): Bradley J. Ridder, Derek J. Leishman, Matthew Bridgland-Taylor, Mohammadreza Samieegohar, Xiaomei Han, Wendy W. Wu, Aaron Randolph, Phu Tran, Jiansong Sheng, Timm Danker, Anders Lindqvist, Daniel Konrad, Simon Hebeisen, Liudmila Polonchuk, Evgenia Gissinger, Muthukrishnan Renganathan, Bryan Koci, Haiyang Wei, Jingsong Fan, Paul Levesque, Jae Kwagh, John Imredy, Jin Zhai, Marc Rogers, Edward Humphries, Robert Kirby, Sonja Stoelzle-Feix, Nina Brinkwirth, Maria Giustina Rotordam, Nadine Becker, Søren Friis, Markus Rapedius, Tom A. Goetze, Tim Strassmaier, George Okeyo, James Kramer, Yuri Kuryshev, Caiyun Wu, Herbert Himmel, Gary R. Mirams, David G. Strauss, Remi Bardenet, Zhihua Li

A Small Molecule Induces Oligodendrogenesis Leading to Myelin Sheath Repair

Journal: Journal of Clinical Endocrinology & Metabolic Disorders
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Author(s): Steven H Nye, James G Yarger

A small molecule activator of Nav1.1 channels increases fast-spiking interneuron excitability and GABAergic transmission in vitro and has anti-convulsive effects in vivo

Author(s): Kristen Frederiksen, Lu Dunguo, Jinhui Yang, Henrik Sindal Jensen, Jesper Frank Bastlund, Peter Hjørringgaard Larsen, Liu Henry, Kim Dekermendjian, Lassina Badolo, Morten Laursen, Charlotte Hougaard, Charles Yang, Niels Svenstrup, Morten Grunnet

A Rational Design of a Selective Inhibitor for Kv1.1 Channels Prevalent in Demyelinated Nerves that Improves their Impaired Axonal Conduction

Author(s): Ahmed Al-Sabi, Declan Daly, Patrick Hoefer, Gemma K. Kinsella, Charles P. E. Metais, Mark Pickering, Caroline Herron, Seshu Kumar Kaza, Kieran J. Nolan, and J Oliver Dolly

A pharmacological synopsis of small molecules, toxins and CiPA compounds targeting human cardiac Kv4.3 channels

Author(s): Brigitte Schombert, Camille Sanson, Sylvie Houtmann, Michel Partiseti and G. Andrees Böhme

A novel substituted aminoquinoline selectively targets voltage-sensitive sodium channel isoforms and NMDA receptor subtypes and alleviates chronic inflammatory and neuropathic pain

Author(s): Tabakoff B1, Ren W2, Vanderlinden L3, Snell LD4, Matheson CJ5, Wang ZJ6, Levinson R7, Smothers CT8, Woodward JJ9, Honse Y10, Lovinger D11, Rush AM12, Sather WA13, Gustafson DL14, Hoffman PL15.

A Novel Modulator of Kv3 Potassium Channels Regulates the Firing of Parvalbumin-Positive Cortical Interneurons

Journal: The Journal of Pharmacological and Experimental Therapeutics
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Author(s): Marcelo D. Rosato-Siri, Erika Zambello, Chiara Mutinelli, Nicoletta Garbati, Roberto Benedetti, Laura Aldegheri, Francesca Graziani, Caterina Virginio, Giuseppe Alvaro and Charles H. Large

A novel acetylcholinesterase inhibitor and calcium channel blocker SCR-1693 improves Aβ25–35-impaired mouse cognitive function

Author(s): Zhengping Zhang, Rong Chen, Wenji An, Chunmei Wang, Gaoyong Liao, Xiaoliang Dong, Aijing Bi, Zhimin Yin

A new electro-optical approach for conductance measurement: an assay for the study of drugs acting on ligand-gated ion channels

Author(s): A. Menegon, S. Pitassi, N. Mazzocchi, L. Redaelli, R. Rizzetto, J. F. Rolland, C. Poli, M. Imberti, A. Lanati & F. Grohovaz

A new classifier-based strategy for in-silico ion-channel cardiac drug safety assessment

Author(s): Hitesh B. Mistry 1), Mark R. Davies 2) and Giovanni Y. DiVeroli 3)

A dipolar cycloaddition reaction to access 6-methyl-4,5,6,7-tetrahydro-1H-[1,2,3]triazolo[4,5-c]pyridines enables the discovery synthesis and preclinical profiling of a P2X7 antagonist clinical candidate

Author(s): Christa C Chrovian, Akinola Soyode-Johnson, Alexander A Peterson, Christine F. Gelin, Xiaohu Deng, Curt A. Dvorak, Nicholas I. Carruthers, Brian Lord, Ian Fraser, Leah Aluisio, Kevin J Coe, Brian Scott, Tatiana Koudriakova, Freddy Schoetens, Kia Sepassi, David J. Gallacher, Anindya Bhattacharya, and Michael A Letavic

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family

Author(s): Samuel D. Robinson, Alexander Mueller, Daniel Clayton, Hana Starobova, Brett R. Hamilton, Richard J. Payne, Irina Vetter, Glenn F. King and Eivind A. B. Undheim

8 hours unattended hERG run with ≥97% success rate and consistent pharmacology results

Author(s): Melanie Schupp, Mads P G Korsgaard

4-Substituted carbamazepine derivatives: conformational analysis and sodium channel-blocking properties

Author(s): Yuki Kanase, Takafumi Kitada, Hidetsugu Tabata, Kosho Makino, Tetsuta Oshitari, Hiromi Ohashi, Takashi Yoshinaga, Hideaki Natsugari, Hideyo Takahashi

1,2,4-Triazolyl 5-Azaspiro[2.4]heptanes: Lead Identification and Early Lead Optimization of a New Series of Potent and Selective Dopamine D3 Receptor Antagonists

Author(s): Fabrizio Micheli*†, Alessia Bacchi§, Simone Braggio†, Laura Castelletti†, Palmina Cavallini†, Paolo Cavanni†, Susanna Cremonesi†, Michele Dal Cin†, Aldo Feriani†, Sylvie Gehanne†, Mahmud Kajbaf†, Luciano Marchió§, Selena Nola†, Beatrice Oliosi†, Annalisa Pellacani†, Elisabetta Perdonà†, Anna Sava†, Teresa Semeraro†, Luca Tarsi†, Silvia Tomelleri†, Andrea Wong†, Filippo Visentini†, Laura Zonzini† and Christian Heidbreder‡

“Clip Detecting” with series resistance compensation using an automated patch clamp system

Author(s): Lars Damgaard Løjkner, Chris Gibbs, Jesper Gerved, Jens Henneke, Jonatan Kutchinsky, Rasmus B Jacobsen, Morten Sunesen