Sophion patch clamp amplifiers are developed in-house. Our amplifiers offer unique features such as adaptive voltage and current clamp, as well as automatic compensation for series resistance (R_s), cell capacitance (C_slow), and up to 300 nA maximal current. These unique features contribute to the quality recordings that are regarded as a hallmark of our Sophion platforms.

• Voltage clamp (conventional and adaptive)
• Current clamp (conventional and adaptive)
• Voltage and current clamp in the same sweep
• Series resistance compensation (R_s) (Up to 100%)
• Cell capacitance compensation (C_slow)
• Minimal noise
• Up to 300 nA maximal current

From the platform of the screening station, a ‘bed-of-nails’ connects the patch clamp electrodes directly with the amplifier front ends. This distance is critical and minimized to reduce any noise pick-up from the surroundings.

Multiple patch clamp amplifiers are implemented on a standard printed circuit board, enabling all amplifiers to be positioned near the patch-clamp electrodes. Due to their small size, Sophion amplifiers are ideally suited for extensive parallelism and provide considerable scalability.