Electrophysiological effects of cisplatin on Nav1.7 currents in lung cancer cells

The VGSC subtype Na_V1.7 is up-regulated in lung cancer cells, where it enhances invasion and metastasis. Platinum-based treatments, like cisplatin, can become less effective over time as the body develops a resistance to them, leading to a reduced response and increased difficulty in managing cancer. In addition to chemoresistance and reduced efficacy, cisplatin has been linked to chemotherapy-induced peripheral neuropathy that might explain associated chronic pain side-effects.