Targeting NaV1.7: How Mechanism-Based Multidisciplinary Research Drives Precision Therapy in Inherited Pain Syndromes –A Translational Approach

Neuropathic pain affects the quality of life of around 8% of the population, but treatment has made only limited progress over the last two decades. Thus, an innovative approach is needed to meet this medical need. At the Scientific Centre for Neuropathic Pain Aachen (SCNAACHEN), we have established an interdisciplinary analysis platform/pipeline to investigate individual sodium channel variants, with a focus on NaV1.7, identified in patients in our SCNAACHEN patient registry suffering from small fibre neuropathy. We aim to address the treatment gap and to advance neuropathic pain research through interdisciplinary and translational research on neuropathic pain mechanisms.