Porphyrin derivatives as potent and selective blockers of neuronal Kv1 channels


Chemical Communications


D. Daly a), A. Al-Sabi b), G. K. Kinsella c), K. Nolan a) and J. O. Dolly b)



Selective inhibitors of voltage-activated K+ channels are needed for the treatment of multiple sclerosis. In this work it was discovered that porphyrins bearing 2–4 carbon alkyl ammonium side chains predominantly blocked the Kv1.1 current whilst Kv1.2 was susceptible to a porphyrin bearing polyamine side chains.

Go to journal

Get in Touch

We strive to provide the best for our customers, and we are always ready to help. Please let us know if you have a question for us.

Follow us