Inhibition of KCa2 Channels Decreased the Risk of Ventricular Arrhythmia in the Guinea Pig Heart During Induced Hypokalemia


Frontiers in Pharmacology


Jonas Goldin Diness, Lea Abildgaard, Sofia Hammami Bomholtz, Mark Alexander Skarsfeldt, Nils Edvardsson, Ulrik S. Sørensen, Morten Grunnet and Bo Hjorth Bentzen



Hypokalemia reduces the cardiac repolarization reserve. This prolongs the QT-interval and increases the risk of ventricular arrhythmia; a risk that is exacerbated by administration of classical class 3 anti-arrhythmic agents.

Small conductance Ca2+-activated K+-channels (KCa2) are a promising new atrial selective target for treatment of atrial fibrillation. Under physiological conditions, KCa2 plays a minor role in ventricular repolarization. However, this might change under hypokalemia because of concomitant increases in ventriculay -60r intracellur Ca2+.

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