TOPIC

Imidazol(ium) lipids for transfection and HCN channel modulation via novel lipidomimetics

Journal

ICMS 2024 UK

Author(s)

Ronewa Nematswerani, Frank Glorius

Year

2024

This research explores imidazol(ium)-based lipids as tools to improve gene delivery and their impact on HCN and Kv7 channels, crucial for heart and brain functions. These lipids incorporate a functionalized alkyl moiety on C2 position, which is crucial for the interaction with genetic material and membranes, making them more effective and easier to synthesize. A recent study found that lipid binding along the S6 helix disrupts a key salt bridge, affecting HCN channel stability. Notably, natural PA can activate HCN2 channels by disrupting this bridge, unlike PIP2.

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