Imidazol(ium) lipids for transfection and HCN channel modulation via novel lipidomimetics
Journal
ICMS 2024 UK
Author(s)
Year
2024
This research explores imidazol(ium)-based lipids as tools to improve gene delivery and their impact on HCN and Kv7 channels, crucial for heart and brain functions. These lipids incorporate a functionalized alkyl moiety on C2 position, which is crucial for the interaction with genetic material and membranes, making them more effective and easier to synthesize. A recent study found that lipid binding along the S6 helix disrupts a key salt bridge, affecting HCN channel stability. Notably, natural PA can activate HCN2 channels by disrupting this bridge, unlike PIP2.