Publications - Sophion

µ-Conotoxins Targeting the Human Voltage-Gated Sodium Channel Subtype NaV1.7

Author(s): Kirsten L McMahon, Hue N T Tran, Jennifer R Deuis, David J Craik, Irina Vetter, Christina I Schroeder

δ-conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails

Journal: Proceedings of the Royal Society B: Biological Sciences
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Author(s): Ai-Hua Jin, Mathilde R. Israel, Marco C. Inserra, Jennifer J. Smith, Richard J. Lewis, Paul F. Alewood, Irina Vetter and Sebastien Dutertre

Voltage-Gated Sodium Channel Modulation by a New Spider Toxin Ssp1a Isolated From an Australian Theraphosid

Author(s): Dongol, Y., Choi, P. M., Wilson, D. T., Daly, N. L., Cardoso, F. C., & Lewis, R. J.

Venom Peptides with Dual Modulatory Activity on the Voltage-Gated Sodium Channel NaV1.1 Provide Novel Leads for Development of Antiepileptic Drugs

Author(s): Chun Yuen Chow, Yanni K.-Y. Chin, Andrew A. Walker, Shaodong Guo, Linda V. Blomster, Micaiah J. Ward, Volker Herzig, Darin R. Rokyta, and Glenn F. King

Venom chemistry underlying the painful stings of velvet ants (Hymenoptera: Mutillidae)

Author(s): Jensen, T., Walker, A. A., Nguyen, S. H., Jin, A.-H., Deuis, J. R., Vetter, I., King, G. F., Schmidt, J. O., & Robinson, S. D.

Two for the Price of One: Heterobivalent Ligand Design Targeting Two Binding Sites on Voltage-Gated Sodium Channels Slows Ligand Dissociation and Enhances Potency

Author(s): Alicia Peschel, Fernanda C. Cardoso, Andrew A. Walker, Thomas Durek, M. Rhia L. Stone, Nayara Braga Emidio, Philip E. Dawson, Markus Muttenthaler, and Glenn F. King

Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain

Author(s): Md. Mahadhi Hasan, Lotten Ragnarsson, Fernanda C. Cardoso, Richard J. Lewis

The Snake with the Scorpion’s Sting: Novel Three-Finger Toxin Sodium Channel Activators from the Venom of the Long-Glanded Blue Coral Snake

Author(s): Daryl C. Yang 1,2,†, Jennifer R. Deuis 3,†, Daniel Dashevsky 2,†, James Dobson 2,†, Timothy N. W. Jackson 2, Andreas Brust 3, Bing Xie 4, Ivan Koludarov 2, Jordan Debono 2, Iwan Hendrikx 2, Wayne C. Hodgson 1, Peter Josh 5, Amanda Nouwens 5, Gregory J. Baillie 3, Timothy J. C. Bruxner 3, Paul F. Alewood 3, Kelvin Kok Peng Lim 6, Nathaniel Frank 7, Irina Vetter 3,8,* and Bryan G. Fry 2,*

The E15R Point Mutation in Scorpion Toxin Cn2 Uncouples Its Depressant and Excitatory Activities on Human NaV1.6

Author(s): Mathilde R. Israel, Panumart Thongyoo, Jennifer R. Deuis, David J. Craik, Irina Vetter, Thomas Durek

Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers

Author(s): Dan Wang, Pratik Neupane, Lotten Ragnarsson, Robert J. Capon and Richard J. Lewis

Structural and functional insights into the inhibition of human voltage-gated sodium channels by μ-conotoxin KIIIA disulfide isomers

Journal: Journal of Biological Chemistry, 298(3), 101728
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Author(s): Tran, H. N. T., McMahon, K. L., Deuis, J. R., Vetter, I., & Schroeder, C. I.

Recombinant production, bioconjugation and membrane binding studies of Pn3a, a selective Nav1.7 inhibitor

Author(s): Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Alexander Mueller, Irina Vetter, Mehdi Mobli

Recombinant Production , Bioconjugation and Membrane Binding Studies of Pn3a , a Selective Nav1.7 Inhibitor

Author(s): Gagan Sharma, Jennifer R. Deuis, Xinying Jia, Alexander Mueller, Irina Vetter, Mehdi Mobli

Rational engineering defines a molecular switch that is essential for activity of spider-venom peptides against the analgesics target Nav1.7

Author(s): Julie K Klint, Yanni K. Y. Chin, and Mehdi Mobli

Pharmacological screening technologies for venom peptide discovery

Author(s): Prashanth JR(1, Hasaballah N(1, Vetter I(2

Pharmacological Inhibition of the Voltage-Gated Sodium Channel NaV1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome

Journal: ACS Pharmacology & Translational Science
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Author(s): Jiang, Y., Castro, J., Blomster, L. V., Agwa, A. J., Maddern, J., Schober, G., Herzig, V., Chow, C. Y., Cardoso, F. C., França, P. D. D. S., Gonzales, J., Schroeder, C. I., Esche, S., Reiner, T., Brierley, S. M., & King, G. F.

Pharmacological characterisation of the highly Nav1.7 selective spider venom peptide Pn3a

Author(s): Jennifer R. Deuis, Zoltan Dekan, Joshua S. Wingerd, Jennifer J. Smith, Nehan R. Munasinghe, Rebecca F. Bhola 2), Wendy L. Imlach, Volker Herzig, David A. Armstrong, K. Johan Rosengren, Frank Bosmans, Stephen G. Waxman, Sulayman D. Dib-Hajj, Pierre Escoubas, Michael S. Minett, Macdonald J. Christie, Glenn F. King, Paul F. Alewood, Richard J. Lewis, John N. Wood & Irina Vetter

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I

Author(s): Kirsten L. McMahon, Bryan Tay, Jennifer R. Deuis, Brian S.Tanaka, Steve Peigneur, Ai-Hua Jin, Jan Tytgat, Stephen G. Waxman, Sulayman D. Dib-Hajj, Irina Vetter, Christina I. Schroeder

Pharmacological activity and NMR solution structure of the leech peptide HSTX-I

Author(s): Kirsten L. McMahon, Bryan Tay, Jennifer R. Deuis, Brian S. Tanaka, Steve Peigneur, Ai-Hua Jin, Jan Tytgat, Stephen G. Waxman, Sulayman D. Dib-Hajj, Irina Vetter, Christina I. Schroeder

Novel Neurotoxic Activity in Calliophis intestinalis Venom. Neurotoxicity Research

Author(s): Dashevsky, D., Deuis, J. R., Vetter, I., Huynh, T., Hodgson, W. C., Tan, C. H., Nouwens, A., & Fry, B. G.

Neurotoxic peptides from the venom of the giant Australian stinging tree

Author(s): Edward K. Gilding, Sina Jami, Jennifer R. Deuis, Mathilde R. Israel, Peta J. Harvey, Aaron G. Poth, Fabian B. H. Rehm, Jennifer L. Stow, Samuel D. Robinson, Kuok Yap, Darren L. Brown, Brett R. Hamilton, David Andersson, David J. Craik, Irina Vetter, Thomas Durek

Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1

Author(s): Marco C. Inserra, Mathilde R. Israel, Ashlee Caldwell, Joel Castro, Jennifer R. Deuis, Andrea M. Harrington, Angelo Keramidas, Sonia Garcia-Caraballo, Jessica Maddern, Andelain Erickson, Luke Grundy, Grigori Y. Rychkov, Katharina Zimmermann, Richard J. Lewis, Stuart M. Brierley & Irina Vetter

Mapping the Molecular Surface of the Analgesic Nav1.7-Selective Peptide Pn3a Reveals Residues Essential for Membrane and Channel Interactions

Author(s): Alexander Mueller, Zoltan Dekan, Quentin Kaas, Akello J. Agwa, Hana Starobova, Paul F. Alewood, Christina I. Schroeder, Mehdi Mobli, Jennifer R. Deuis, and Irina Vetter

Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype

Author(s): Akello J. Agwa, Poanna Tran, Alexander Mueller, Hue N. T. Tran, Jennifer R. Deuis, Mathilde R. Israel, Kirsten L. McMahon, David J. Craik, Irina Vetter and Christina I. Schroeder

Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens

Author(s): Fernanda C. Cardoso, Zoltan Dekan, K. Johan Rosengren, Andelain Erickson, Irina Vetter, Jennifer R. Deuis, Volker Herzig, Paul F. Alewood, Glenn F. King, and Richard J. Lewis

Evaluation of Efficient Non-reducing Enzymatic and Chemical Ligation Strategies for Complex Disulfide-Rich Peptides

Author(s): Tran, H. N. T., Tran, P., Deuis, J. R., McMahon, K. L., Yap, K., Craik, D. J., Vetter, I., & Schroeder, C. I.

Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel Nav1.7 Inhibition

Author(s): Hue N. T. Tran, Hue N. T. Tran, Poanna Tran, Jennifer R. Deuis, Akello J. Agwa, Alan H. Zhang, Irina Vetter, and Christina I. Schroeder

Enzymatic Ligation of a Pore Blocker Toxin and a Gating Modifier Toxin: Creating Double-Knotted Peptides with Improved Sodium Channel Nav1.7 Inhibition

Author(s): Hue N. T. Tran, Poanna Tran, Jennifer R. Deuis, Akello J. Agwa, Alan H. Zhang, Irina Vetter and Christina I. Schroeder

Efficient Enzymatic Ligation of Inhibitor Cystine Knot Spider Venom Peptides: Using Sortase A To Form Double-Knottins That Probe Voltage-Gated Sodium Channel NaV1.7

Author(s): Agwa AJ, Blomster LV, Craik DJ, King GF, Schroeder CI.

Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi

Author(s): Silmara R. Sousa, Joshua S. Wingerd, Andreas Brust, Christopher Bladen, Lotten Ragnarsson, Volker Herzig, Jennifer R. Deuis, Sebastien Dutertre, Irina Vetter, Gerald W. Zamponi, Glenn F. King, Paul F. Alewood, Richard J. Lewis

Diindolylmethane Derivatives: New Selective Blockers for T-Type Calcium Channels

Author(s): Wang, D., Neupane, P., Ragnarsson, L., Capon, R. J., & Lewis, R. J.

Development of a high-throughput fluorescent no-wash sodium influx assay

Author(s): Bryan Tay, Teneale A. Stewart, Felicity M. Davis, Jennifer R. Deuis, Irina Vetter

Characterization of Synthetic Tf2 as a Nav1.3 Selective Pharmacological Probe

Author(s): Mathilde R. Israel, Thomas S. Dash, Stefanie N. Bothe, Samuel D. Robinson, Jennifer R. Deuis, David J. Craik, Angelika Lampert, Irina Vetter and Thomas Durek

Characterization of Synthetic Tf2 as a Nav1.3 Selective Pharmacological Probe

Author(s): Mathilde R. Israel, Thomas S. Dash, Stefanie N. Bothe, Samuel D. Robinson, Jennifer R. Deuis, David J. Craik, Angelika Lampert, Irina Vetter and Thomas Durek

Characterisation of δ-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator

Author(s): Dan Wang, S.W.A. Himaya, Jean Giacomotto, Md. Mahadhi Hasan, Fernanda C. Cardoso, Lotten Ragnarsson and Richard J. Lewis

Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of Nav1.7-Mediated Pain

Author(s): Jennifer R. Deuis 1,2, Joshua S. Wingerd 1, Zoltan Winter 3, Thomas Durek 1, Zoltan Dekan 1, Silmara R. Sousa 1, Katharina Zimmermann 3, Tali Hoffmann 3, Christian Weidner 3, Mohammed A. Nassar 4, Paul F. Alewood 1, Richard J. Lewis 1 and Irina Vetter 1,2,*

A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome

Author(s): Cardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M., Lewis, Richard J.

A Selective Nav1.1 Activator with Potential for Treatment of Dravet Syndrome Epilepsy

Author(s): Chun Yuen Chow, Yanni K.Y. Chin, Linlin Ma, Eivind A.B.Undheim, VolkerHerzig, Glenn F. King

A Selective Nav1.1 Activator with Potential for Treatment of Dravet Syndrome Epilepsy

Author(s): Chun Yuen Chow, Yanni K. Y. Chin, LinlinMa, Eivind A. B. Undheim, Volker Herzig, Glenn F. King

A comprehensive portrait of the venom of the giant red bull ant, Myrmecia gulosa, reveals a hyperdiverse hymenopteran toxin gene family

Author(s): Samuel D. Robinson, Alexander Mueller, Daniel Clayton, Hana Starobova, Brett R. Hamilton, Richard J. Payne, Irina Vetter, Glenn F. King and Eivind A. B. Undheim