Neurons webinar recording:
Advancing neurodegenerative and neurodevelopmental drug discovery by investigating iPSC-derived excitatory neurons using automated patch clamp
Yesterday, guest speaker Scott Schachtele from FUJIFILM Cellular Dynamics and Sophion’s Kadla Røskva Rosholm shared their experiences with iPSC-derived excitatory neurons in a webinar, presenting valuable insights and a glimpse into the future of neuroscience research.
First, Scott Schachtele highlighted the advantages of using forward programmed excitatory neurons for high throughput drug discovery and compound screening. He also introduced a new cellular model of frontotemporal dementia (FTD), using NGN2-induced excitatory neurons that are heterozygous for the GRN R493X mutation. Following this, Kadla Røskva Rosholm showcased an automated patch clamp assay for high-throughput evaluation of electrophysiological disease phenotypes in commercially available frontotemporal dementia (FTD) hiPSC-derived excitatory neurons. The recorded data include high-throughput recordings of voltage-gated (Kv, Nav), ligand-gated (AMPA) ion channel currents, as well as neuron excitability to identify differences between FTD and WT neurons.
Click below to listen to the iPSC-derived excitatory neurons webinar recording now and fast-track your breakthroughs in neurodegenerative disease research with unmatched precision and efficiency!