Sophion webinar recording: Pushing boundaries in organelle electrophysiology using Sophion’s automated patch clamp technology for lysosomal and mitochondrial ion channel investigations
Last week, guest speaker Manuel Paina from Axxam together with Sophion’s Eliška Waloschková and hosted by Sophion’s Daniel Rafael Peter Sauter, led a webinar highlighting how automated patch clamp technology is opening new frontiers in organelle research, with a focus on lysosomal and mitochondrial ion channel investigations.
Manuel Paina from Axxam opened the session by explaining the rationale for targeting mitochondrial ion channels and demonstrated assay development and optimization on the QPatch platform, covering mitochondrial isolation protocols, QPlate development, and a case study on the calcium uniporter. The presentation highlighted how automated patch clamp can accelerate organelle research and uncover new therapeutic opportunities.
Sophion’s Eliška Waloschková then shared practical insights into organelle automated patch clamp using Sophion systems. Highlighting our newly optimized consumables for high resistance electrophysiology, Eliška provided guidance on how to achieve higher success rates with ready-to-use lysosomal samples from Oria Bioscience. She also demonstrated principles for tailoring ion channel-specific assays, illustrated with a practical example on TRPML1.
In this webinar, you will learn how medium- and high-throughput automated patch clamp platforms are advancing organelle ion channel research, overcoming challenges in organelle electrophysiology, accelerating discoveries on intracellular channels, and unlocking new opportunities in medicine and drug discovery.