New publications: latest novel ion channel science from Sophion users in Q1 2025
Sophion users continue to innovate in ion channel research in the Q1 2025 quarterly review of peer-reviewed papers. There’s a variety of publications covering a multitude of ion channels, diseases, and innovative developments for the entire ion channel community.
This quarter, key studies focus on non-opioid pain management and AI-driven drug design. Selected publications highlights include:
- Osteen et al., provide a thorough characterization of Suzetrigine (Journavx, VX-548) for the treatment of pain
- Ghovanloo et al. (increasingly regular contributors to this review), show that cannabinoids (CBG, CBD, CBN) inhibit Nav1.8, suggesting potential for novel forms of pain therapeutics.
- In groundbreaking work with Nobel prizewinner David Baker’s lab, Vazquez-Torres et al., used AI generative methods to make de novo venom toxin binders, creating a novel form of snakebite anti-venoms