Publications - Sophion

Voltage- and current clamp on induced pluripotent cardiomyocytes with automated patch clamp

Author(s): Daniel Sauter, Anders Lindqvist, Rasmus Bjørn Jacobsen, Jens Henneke, Mads P.G. Korsgaard

Use- and state-dependent Nav1.5 blockers on QPatch X and in vivo and in vitro assays

Author(s): M Knirke Jensen, Tomoko Sakakura, Yasuyuki Abe, Hideo Takamori, Kiyoshi Takasuna, Yuji Tsurubuchi, Morten Sunesen

Upscaling and automation of electrophysiology: toward high throughput screening in ion channel drug discovery

Author(s): M Asmild, N Oswald, KM Krzywkowski, S Friis, RB Jacobsen, D Reuter, R Taboryski, J Kutchinsky, RK Vestergaard, RL Schrøder, CB Sørensen, M Bech, MP Korsgaard, NJ Willumsen

TRP’ing in multi-hole mode

Author(s): Rasmus B Jacobsen, Hervør L Olsen

Transient expression of the NMDA receptor in HEK cells co-expressing the glutamate transporter for the screening of potential positive allosteric modulators of NR2B

Author(s): Michael J Morton, John Malone, Paul Sharpe, Graham Sproat, Malcolm Haddrick, Joe Mather

TMEM16A on Qube 384

Author(s): Joseph G. McGivern*, John K. Sullivan*, Kathryn A. Henckels*, Paul Wang*, David Powers*, Daniel Sauter**, Lars Løjkner**, Rasmus Jakobsen**, Mads Korsgaard**

Temperature effect on hERG channel pharmacology measured using the Qube automated patch clamp system

Author(s): Anders Lindqvist, Mette Christensen, Rasmus Jacobsen, Göran Mattson

Strategies for enhancing throughput in ion channel drug screening

Author(s): Rasmus B. Jacobsen, Naja M. Sørensen, Hervør L. Olsen, M. Sunesen, *Niels J. Willumsen

Sophion analyzer as a tool for biophysical and pharmacological characterization of eight Nav subtypes evaluated in parallel on Qube

Author(s): Mads P. G. Korsgaard, Lars Damgaard Løjkner, Anders Lindqvist, Mette T Christensen, Thomas Binzer

Simple and Effective Generation of Cell-based Assays for Ion Channels, Transporters, and Kinase Screening in Biologically Relevant Cells Using Scalable Transient Transfection

Author(s): Qin (Ching) Chen, James Brady, Karen Donato, Meg Duskin, and Madhusudan Peshwa

Scaffolds within scaffolds: Generating ion channel blocking antibodies by fusing knottin to peripheral CDR loops

Author(s): A.Karatt-Vellatt1, S. Surade1, D. C. Bell1, T. Leutkens1, E. Masters1, A.M. Luther1, N.M. Sørensen2, N. Butt1 & J. McCafferty1

Rapid generation of cells for ion channels assays: Efficient, large scale transfection using the MaxCyte STX

Author(s): James Brady, Peer Heine, Rama Shivakumar, Angelia Viley, Madhusudan Peshwa, Karen Donato and Krista Steger - MaxCyte Mark Rothenberg. Corning Inc., Kennebunk, ME, USA. Hervør Lykke Olsen, Nikolaj Nielsen, Kristina Christensen, Jeffrey Webber and Morten Sunesen - Sophion Bioscience

Qube as a tool for assay optimization of CiPA cells and protocols by using multiple IC, EC solutions and hERG, Nav1.5 and Cav1.2 on the same QChip

Author(s): Melanie Schupp, Anders Lindqvist, Pia Bladsgaard Andersen, Weifeng Yu

Qube 384-channel patch clamp characterization of the liquid flow channels

Author(s): Rasmus B Jacobsen, Søren Friis, Hervør L Olsen, Mette T Christensen, Kristina M Christensen, Peder S Pedersen, Anders Hyldgaard, Morten Sunesen, Anders Lindqvist

Qube 384 channel patch clamp screening system ligand gated ion channel applications

Author(s): Søren Friis, Rasmus B Jacobsen, Hervør Lykke Olsen, Mette T Christensen, Kristina M. Christensen, Peder Skafte Pedersen, Lasse Homann, Morten Sunesen, Anders Lindqvist

Preparation, Antiepileptic Activity, and Cardiovascular Safety of Dihydropyrazoles as Brain-Penetrant T-Type Calcium Channel Blockers

Author(s): Lubos Remen†, Olivier Bezençon*†, Lloyd Simons‡, Rick Gaston‡, Dennis Downing‡, John Gatfield†, Catherine Roch†, Melanie Kessler†, Johannes Mosbacher†, Thomas Pfeifer†, Corinna Grisostomi†, Markus Rey†, Eric A. Ertel†, and Richard Moon†

Pharmacological characterization of voltage- and ligand-gated ion channels

Author(s): Hervør L Olsen, Rasmus B Jacobsen, Søren Friis, Morten Sunesen, Niels Willumsen, Rikke Schrøder, Naja M Sørensen, M Knirke Jensen

Parallel patch clamp of alpha 7 nicotinic acetylcholine receptor channels

Author(s): Søren Friis, Morten Sunesen, Chris Mathes, Mark Bowlby, John Dunlop, Niels Willumsen

Optimizing CHO hERG for automated patch clamping

Author(s): Søren Friis, Hervør L Olsen, Jeffrey Webber, M Knirke Jensen, Dorthe Nielsen, Morten Sunesen, Chris Mathes

High Throughput Electrophysiology: New Perspectives for Ion Channel Drug Discovery

Author(s): Niels J. Willumsen, Morten Bech, Søren-Peter Olesen, Bo Skaaning Jensen, Mads P. G. Korsgaard, and Palle Christophersen

Exploring stem cell-derived cardiomyocytes with automated patch clamp techniques

Author(s): Rikke P Schrøder, Mette T Christensen, Blake Anson, Morten Sunesen

Evaluation of throughput and data quality

Author(s): Hervor L Olsen, Rikke P Schrøder, Rasmus B Jacobsen, Søren Friis, Morten Sunesen

Enhancing throughput with multiple cell lines per well with the QPatch HTX

Author(s): Hervor L Olsen, Rikke P Schrøder

Enhancing throughput with multiple cell lines per well

Author(s): Hervor L Olsen, Dorthe Nielsen, Morten Sunesen

Endogenous Ion Channels of Mammalian Cell Lines Characterization

Author(s): Søren Friis, Rasmus B Jacobsen, Morten Sunesen, Dorthe Nielsen, Nadia Larsen, Chris Mathes, Niels Willumsen

Electrophysiological properties of iCell cardiomyocytes obtained by automated patch clamp

Author(s): Rikke P Schrøder 1), Mette T Christensen 1), Giorgia Salvagiotto 2), Blake Anson 2), Morten Sunesen 1)

Electrophysiological characterization of human induced pluripotent stem cell-derived dopaminergic neurons using manual and automated patch clamp systems

Author(s): Denise Franz, Jan Giemsa, Oliver Klink, Hervør Lykke Olsen

Development of an Ultra High-Throughput Screen to Identify Antagonists for GluK1

Author(s): Kelli Solly1 , Carissa Quinn1 , Rebecca Klein2 , Darrel Henze 2 , Eric Johnson1 , and Michael Finley 1

Data quality is not affected by cell suspension density

Author(s): Chris Mathes, Hervør L Olsen, Michael Stoltenborg, Morten Sunesen, Niels Willumsen

Chemoselective tarantula toxins report voltage activation of wild-type ion channels in live cells

Author(s): Drew C. Tilleya (1, Kenneth S. Euma, (b,1,2, Sebastian Fletcher-Taylora, Daniel C. Austina, Christophe Dupréb, Lilian A. Patrónb, Rita L. Garciac, Kit Lamd, Vladimir Yarov-Yarovoya,d, Bruce E. Cohenc, and Jon T. Sacka,b (3

Characterization of hERG blockers using the automated QPatch 16 screening system

Author(s): Rasmus B Jacobsen, Simon Pedersen, Søren Friis, Nicoline Andersen, Niels Willumsen

Biophysical and pharmacological profiling of multiple Nav subtypes on QPatch HT

Author(s): Anders Lindqvist, Søren Friis, Mette T. Christensen & Mads P.G. Korsgaard

Biophysical and pharmacological characterization of multiple Nav subtypes on Qube

Author(s): Anders Lindqvist, Søren Friis, Mette T. Christensen & Mads P.G. Korsgaard

Biophysical and pharmacological characterization of ligandgated ion channels in multi-hole mode

Author(s): M. Knirke Jensen, Rikke Schrøder, Hervør L. Olsen, Rasmus B. Jacobsen, Jeffrey Webber, Søren Friis, Dorthe Nielsen, Mette T. Christensen, Morten Sunesen

Automation of patch clamp techniques: Technical validation through characterization of voltage-gated potassium channels and ligand-gated ion channels

Author(s): Karen Krzywkowski, Rikke Schrøder, Trine Ljungstrøm, Jonatan Kutchinsky, Søren Friis, Margit Asmild, Rafael Taborski, Simon Pedersen, Ras K. Vestergaard, Rasmus B Jacobsen, Nathalie Helix, Claus B Sørensen Morten Bech, Jeppe K Christensen, Simon du Beau, Niels Willumsen

Automated Patch-Clamp Technique: Increased Throughput in Functional Characterization and in Pharmacological Screening of Small-Conductance Ca2+ Release-Activated Ca2+ Channels

Author(s): Rikke L. Schrøder 1), Søren Friis 1), Morten Sunesen 1), Chris Mathes 2), and Niels J. Willumsen 3)

Assessing functional properties of ligand-gated ion channels with automated whole-cell patch clamp technology

Author(s): Hervør L Olsen, Rasmus B Jacobsen, Rikke Schrøder, Jonatan Kutchinsky, Morten Sunesen, Niels Willumsen

Are stem-cell cardiomyocytes a viable cellular reagent for automated patch-clamp?

Author(s): Michael Morton, Lauren Eades

Application of QPatch 16 for drug screening of ligand-gated ion channels

Author(s): Nicoline R. Andersen, Simon Pedersen, Jeppe K. Christensen, Michael Stoltenborg, Morten Sunesen, Niels J. Willumsen

“Clip Detecting” with series resistance compensation using an automated patch clamp system

Author(s): Lars Damgaard Løjkner, Chris Gibbs, Jesper Gerved, Jens Henneke, Jonatan Kutchinsky, Rasmus B Jacobsen, Morten Sunesen