Latest advances in stem cell recordings on APC reviewed

A Sophion authored pluripotent stem cells and APC review paper shows the much-vaunted use of hiPSC in biomedical research is drawing closer to the promise they hold for safety pharmacology, drug discovery, and personalized medicine.

Research scientist Kadla Røskva Rosholm, Ph.D., and colleagues at Sophion Bioscience, in conjunction with co-authors Prof. Niels Voigt and scientist Fitzwilliam Seibertz of the University of Göttingen have written a wide-ranging review of techniques and applications of hiPSC, developments driven by high-throughput APC.

This figure illustrates paced action potentials in 10 individual hiPSC-cardiomyocyte current clamp recordings from a single measurement QPlate. The expanded action potential shows typical AP characterization measurements: threshold potential (Vt), peak potential (Vp), hyperpolarization potential (Vh), and action potential duration at 90% repolarization (APD90).

View the full, open access paper here

iPSC-derived motor neurons on Qube and QPatch

High success rates and significant differences in diseased versus control cells from Amyotrophic Lateral Sclerosis and Spinal Muscular Atrophy patients open for a whole new role for automated patch clamp in relation to neurological diseases. BrainXell has provided cells enabling this work.

Read the report here.

hiPSC motor neurons on Qube and QPatch

Neurological diseases like Amyotrophic Lateral Sclerosis are detrimental in their nature and not easy to treat. In the search for new interventions it is necessary with model systems to test molecules, genetic modifiers etc. We can record both healthy, diseased and rescued hiPSC on our instruments. Read more here.