CiPA Archives - Sophion

First CiPA Paper is published in Nature Scientific Reports

We are happy to see results from the first large CIPA study that has been published in Nature Scientific Reports. The study was co-authored by Sophions own Anders Lindqvist, but lots of credit should also go to the rest of the team.

  • Kramer et Al. (2020) “Cross-site and cross-platform variability of automated patch clamp assessments of drug effects on human cardiac currents in recombinant cells”, Nature Scientific Reports volume 10, Article number: 5627

Results from this large multi-site study provide estimates of the variability associated with IC50 values characterizing the blocking potency of 12 drugs on 4 prominent human cardiac currents using suggested experimental protocols across five automated patch platforms and 17 sites.

QPatch results were provided by ourselves and three independent QPatch users (4 in all) and while platforms are anonymized in the paper we can still say that results confirmed what we already knew.

For the record QPatch data was only run at room temperature. With the newly launched temperature control module for QPatch II that enables accurate control of temperature within a range from 10-42°C with a precision of ±0.5°C, we look forward to running more cardiac assays at elevated temperatures. Read more about the QPatch II temperature control solution here.

Also, the original instructions from the Food and Drug Administration (FDA) did not recommend the use of fluoride in the solutions. For most assays on Sophion ‘Qube 384’ we use fluoride to increase the seal resistance, and since it was not recommended, Qube was omitted from this study. We have now learned that others have used fluoride/seal enhancers during this study and agreed with FDA to include Qube in future CiPA studies. We look forward to that since many laboratories already are using Qube for cardiac liability testing.

For questions please contact Sr. Application Scientist Anders Lindqvist

Sophion Seminar & Workshop – Japan

You are invited to the Sophion Seminar & Workshop in Japan at Sophion Bioscience K.K.’s premises:


Waseda Research Park
1011 Nishitomida, Honjo, Saitama 367-0035, Japan



10:00          Registration

10:30          Welcome remarks and safety briefing
Dr. Yuji Tsurubuchi, Country Manager, Sophion Bioscience K.K., Japan

10:40          New ownership and future strategy at Sophion (tentative)
Mr. Thais Johansen, CEO, Sophion Bioscience A/S, Denmark

11:00          Educational lecture: Redox Physiology of TRP channels
Prof. Yasuo Mori, Laboratory of Molecular Biology, Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Japan

12:00          Lunch break and new Sophion K.K. lab tour
Each participant is assigned to either group A or B at the time of registration. The tour starts at 12:00 and 12:45 for group A and B, respectively. Lunch is served for group A after the tour.

13:30          Potency of ReproNeuro “Human iPS derived neurons” in the drug discovery support
Dr. Makoto Honda, ReproCELL, Inc., Japan

13:50          iPS derived human cells; iCel®, MyCell® DDP/ “disease in a dish” and ideas of application for drug discovery
Dr. Ko Zushida, Cellular Dynamics International Japan Co., Ltd.

14:20          Using the QPatch HTX to drive drug discovery: ligand-gated ion channels
Dr. Robert E. Petroski, Scientist IV/Manager Neurophysiology, Dart Neuroscience LLC, USA

15:00          Coffee break

15:30          Targeting T-type calcium channel for anti-pain drug discovery
Dr. Norio Hashimoto, Nissan Chemical Industries, Ltd., Japan

16:10          Exemplar of optical recording from neural and cardiac activities
Mr. Kenji Tsubokura, Brain Vision Co., Ltd., Japan

16:30          CiPA – novel drug safety assessment
Ms. Melanie Schupp, Application Scientist, Sophion Bioscience A/S, Denmark

16:50          Closing remarks
Mr. Naoto Ueda, President & CEO, Physio-Tech Co., Ltd., Japan

16.55          Bus transportation to the venue of reception

17:30          Reception (food and beverages are served)
Saitama Grand Hotel Honjo

19:30          Bus transportation to Honjo Waseda Station