Voltage and current clamp recordings of Cor.4U® human iPS cell-derived cardiomyocytes using Sophion’s QPatch - Sophion

Voltage and current clamp recordings of Cor.4U® human iPS cell-derived cardiomyocytes using Sophion’s QPatch


Journal: Sophion application report
View file
Author(s): Daniel Sauter


  • High fidelity voltage and current clamp recordings of Cor.4U in physiological solution
  • Demonstration of the presence of INa, ICa as well as IKr
  • The use of fluoride in the internal solution resulted in lower
    ICa and shortened action potential durations
  • Paced and spontaneous action potentials
  • Pharmacological agents show expected effects on action
    potentials in Cor.4U
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