Large Molecules: Wnt signal activation - Sophion

Large Molecules: Wnt signal activation


Author(s): Kim Boddum, Naja Møller, Aamir Ahmed


It was possible to obtain both manual and automated patch clamp (APC) recordings of the labile and scarce Wnt proteins (350-400 AA, 35-45 kDa) after thorough optimisation of compound handling.

Here we highlight aspects of handling of Wnt proteins optimised for APC testing, which could also be applied to other large molecules (e.g. toxins, peptides, antibodies).

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