High throughput screening for mode-of-action on Nav1.7 - Sophion

High throughput screening for mode-of-action on Nav1.7


Author(s): Daniel Sauter


  • Constantly high success rates (99% in 3 experiments)
  • Giga-ohm seal resistances in almost all wells
  • Very low data spread
    • All CV values of DMSO control below 10%
    • No false positives with cutoff criteria 3 X SD
    • Z’ constantly greater 0.75
  • Discrimination between different modes of inhibition (state-dependency)
  • Up to 384 individual IC50 values (3072 data points) determined in just one experiment
  • Using Qube in combination with Stacker it would be possible to determine up to 7680 IC50 (60,000 data points) per 24 hours
Contact

Contact Sophion

Sophion Bioscience A/S
Baltorpvej 154, 2750 Ballerup, Denmark
Telephone: +45 44 60 88 00

You need to fill in all required fields.

When opting-in for our newsletter you will receive 4-6 newsletters per year. You can always opt-out directly from the newsletters. For more information see our privacy policy