Temperature control for Qube 384
Qube offers the ability to record high fidelity electrophysiological effects at varying temperatures. Control of the temperature is embedded in the Viewpoint software that is used to control Qube.
With temperature sensors placed very close the recording sites, the feedback loop ensures a stable experiment. The actual temperature reading is also available as data and hence for analysis.
The temperature can be both raised and lowered compared to the ambient temperature. This allows for even more sophisticated experiments on the 384-platform.
Features & Benefits:
- can be elevated to 40 °C
- can be reduced to 5-8 °C above the dew point in the surrounding environment
- varies maximally +/- 1.6 °C across the plate
- varies maximally +/- 1 °C during the experiment
Temperature control of the recording chamber allows:
- Screening and quantification of temperature effects on ion channel targets
- Constant conditions for your experiments irrespective of the surroundings
- Experiments to be performed at physiological temperatures
For screening, it is important to have constant conditions for the experiments. Some laboratories do not have climate control and it then becomes relevant that Qube is able to set and control the temperature in the recording chamber irrespective of the temperature in the laboratory.
Also, consider the temperature sensitivity of ion channel kinetics and pharmacology which can be studied on Qube with temperature control. For example, hERG that has accelerated activation and deactivation kinetics as well as elevated sensitivity to various compounds when the temperature is raised from 18 to 34 °C. See application report here.