Temperature control for QPatch
Controlling the temperature of your experiment standardizes the testing environment and reduces outside influences. Both QPatch and Qube now feature the ability to control the temperature enabling experiments to be performed at physiological temperatures.
Due to the risk of the fatal arrhythmia Torsade de Pointes, all drug candidates are tested for their potential modulation of the cardiac ion channel hERG. Some hERG-blockers are more potent at physiological temperatures than at lower temperatures, and their potency may, therefore, be underestimated when tested at room temperature.
The QPatch and the Qube temperature box use water to control the recording chamber’s temperature. Applications include better elucidation of ion channel kinetics and toxicity data that are more closely aligned to the physiological reality.
Features & Benefits:
- Ensures a constant defined temperature during the day, year or between sites.
- Increases temperature to physiological conditions (35-37°C).
- Decreases temperature to slow down kinetics, study temperature dependence, testing on insect cells etc.