Programme
Day one – wednesday
08.00 Registration and tea/coffee
09.00 Welcome remarks
Session 1 – Professor Stephen Tucker – University of Oxford, UK
09.15 Dr Guillaume Sandoz – University of Côte d’Azur, France
Migraine-associated TRESK mutations increase neuronal excitability through alternative translation initiation and inhibition of TREK
09.40 Dr. Marcus Schewe – Christian-Albrechts-Universität zu Kiel, Germany
A Pharmacological master key mechanism that unlocks the selectivity filter gate in K+ channels
10.05 Professor Sarosh Irani – University of Oxford, UK
Autoantibodies in the human brain: how immunology upsets neurons
10.30 Tea/Coffee, Exhibits and Posters
11.15 Professor Sylvie Ducki – Institut de Chimie de Clermont-Ferrand, France
TREK-1 activation to solve the opioid crisis?
11.40 Professor Slav Bagriantsev – Yale University, USA
Cellular and molecular basis of mechanosensory specialization
12.05 Dr David Hackos – Genentech, USA
Structural basis of toxin binding to voltage-gated sodium channels and what it teaches us about voltage-gating mechanisms
12.30 Lunch
Session 2 – Professor David Wyllie – Edinburgh University, UK
14.00 Dr Paul Wright – LifeArc, UK
A ‘Target-class’ approach to identifying novel activators of K2P channels
14.25 Professor Fusao Kato – Jikei University, Japan
Molecular conversion of presynaptic P2X receptor subtype at brainstem synapse
14.50 Dr Sung-Young Kim – Daewoong Pharmaceutical Co., Ltd.
Drug development strategies of Nav1.7 blocker
15.15 Tea/coffee, exhibits and posters
16.00 Professor Jack Mellor – Bristol University, UK
SK channel regulation of synaptic plasticity
16.25 Professor Isabel Pérez-Otaño – Alicante Institute of Neuroscience, Spain
Juvenile NMDA receptors containing the GluN3A subunit: gatekeepers of synapse plasticity, cognition and brain disease
16.50 Professor Thomas Jentsch – Max-Delbrueck-Center Berlin, Germany
The ClC-2 chloride channel and its role in aldosterone secretion
17.15 Wrap up
17.30 Drinks reception in the Scholar’s Garden
18.30 Dinner in the Great Hall of Clare College
Day 2 – thursday
08.00 Tea/coffee
09.00 Welcome remarks
Session 3 – Professor David Beech – Leeds University, UK
09.05 Professor Stefan Feske – New York University, USA
Ion Channels in Immunity: CRAC channels and beyond
09.30 Professor Dr Marc Freichel – University of Heidelberg, Germany
Regulating pathological cardiac remodelling via TRPC channels and new players in endo-lysosomal Ca2+ signalling
09.55 Professor Insuk So – Seoul National University, Korea
TRPC1 as a negative regulator for TRPC4 and TRPC5 channels
10.20 Tea/coffee, exhibits and posters
11.20 Professor Alex Sobolevsky – Columbia University, USA
Structural and functional studies of vanilloid subtype TRP channels
11.45 Professor Thomas Voets – KU Leuven, Belgium
Temperature-sensitive TRP channels as drug targets
12.10 Professor Yoshihiro Kubo – National Institute for Physiological Sciences (NIPS), Japan
Phosphoinositides modulate the voltage dependence of Two-Pore Channel 3
12.35 Lunch
Session 4 – Professor Annette Dolphin – University College London, UK
14.00 Professor Mala Shah – University College London, UK
Function and modulation of axonal KV7 channels in hippocampal neurons
14.25 Professor Fredrik Elinder – Linköping University, Sweden
Resin-acid derivatives open potassium channels via the voltage-sensor domain – a putative anti-seizure action
14.50 Dr Paul Miller – University of Cambridge, UK
Insights into understanding and developing modulators of GABA-A receptors
15.15 Professor Dimitri Kullmann – University College London, UK
Ion channel gene therapy for refractory epilepsy
15.40 Wrap up