Programme
Day one – wednesday
08.00 AM Sign-in – tea/coffee
09.00 AM Welcome remarks – Thais Johansen, Sophion Bioscience & John Dunlop, Amgen
Session 1 – Chair: Dr Andrew Marks – Columbia University
09.15 AM Dr Isabelle Baconguis
Architecture of the proteolysis-regulated epithelial sodium channel
09.40 AM Professor Yasushi Okamura – Osaka University
Regulation of ion channels by distribution of phospholipids in mouse sperm
10.05 AM Professor Anjali Rajadhyaksha – Weill Cornell Medicine
L-type Ca2+ channel neural mechanisms in addiction-related behavior
10.30 AM Tea/coffee – exhibits and posters
Session 2 – Professor Derek Bowie – McGill University
11.15 AM Dr Andrew Marks – Columbia University
Structure and function of ryanodine receptor in disease of heart and skeletal muscle
11.40 AM Dr Vera Moiseenkova-Bell – University of Pennsylvania
Molecular Mechanisms of TRPV Channels Gating Revealed by Cryo-EM
12.05 PM Dr Paul Colussi – Tetragenetics
Discovery of functional monoclonal antibodies against Kv1.3 and kCa3.1 using the TetraExpressTM protein expression platform
12.30 PM Lunch
Session 3 – Professor Diane Lipscombe – Brown University
02.00 PM Professor Al George – Northwestern University
Decrypting human ion channel variants of unknown significance
02.25 PM Professor Geoffrey Abbott – University of California, Irvine
Direct activation of potassium channels by neurotransmitters and ancient medicines
02.50 PM Dr Anna Greka – Broad Institute of MIT
Ion channel targeted therapy for rare disease
03.15 PM Professor Bruce Bean – Harvard
Strategies for selective neuronal inhibition
03.40 PM Reception and Poster Session
05.30 PM Drinks and buffet dinner
Day 2 – thursday
08.00 AM Tea/coffee
09.00 AM Welcome remarks
Session 4 – Dr John Dunlop – Amgen
09.05 AM Dr Yonghong Bai – Amgen
Structural basis for pharmacological modulation of the TRPC6 channel elucidated by cryo-EM
09.30 AM Professor Derek Bowie – McGill University
Structural underpinnings of ionotropic glutamate receptor activation
09.55 AM Professor Len Kaczmarek – Yale University
Regulation of cellular signaling by potassium channels
10.20 AM Tea/coffee – Exhibit and Posters Session
Session 5 – Dr John Dunlop – Amgen
11.00 AM Professor Toshihisa Osaki – University of Tokyo
Artificial cell membrane platforms for functional analyses and drug screenings of ion channels
11.25 AM Dr Owen McManus – Q-State Biosciences
Using optogenetic assays to identify sodium channel inhibitors as pain therapeutics
11.50 AM Dr Saverio Gentile – University of Illinois
Potassium channel activity unveils cancer vulnerability: from signaling to precision medicine
12.15 PM Lunch – Exhibits and Poster Session
Session 6 – Professor Derek Bowie – McGill University
01.15 PM Professor Diane Lipscombe – Brown University
Epigenetic control of nociceptor-specific calcium channel splice isoforms in health and disease
01.40 PM Dr Bryan Moyer – Amgen
Multi-modality approach to identify NaV1.7 inhibitors for pain
02.05 PM Professor Amy Lee – University of Iowa
Voltage-gated Ca2+ channels of the retina: new insights into CaV1.4 channelopathies
02.30 PM Tea/coffee
03.10 PM Professor Ellen Lumpkin – University of California, Berkeley
TTX-sensitive sodium channels mediate action potential firing in menthol-sensitive neurons of the dorsal root ganglion
03.35 PM Dr Daniel Sauter – Sophion Bioscience
Towards more physiological assays: iPSC-derived neurons tested on the 384 channel automated patch clamp platform Qube
04.00 PM Wrap up