ICMS2019 Boston - program - Sophion


Day one – wednesday

08.00 AM          Sign-in – tea/coffee


09.00 AM          Welcome remarks – Thais Johansen, Sophion Bioscience & John Dunlop, Amgen


Session 1 – Chair: Dr Andrew Marks – Columbia University


09.15 AM      Dr Isabelle Baconguis

Architecture of the proteolysis-regulated epithelial sodium channel


09.40 AM      Professor Yasushi Okamura – Osaka University

Regulation of ion channels by distribution of phospholipids in mouse sperm


10.05 AM      Professor Anjali Rajadhyaksha – Weill Cornell Medicine 

L-type Ca2+ channel neural mechanisms in addiction-related behavior


10.30 AM       Tea/coffee – exhibits and posters


Session 2 – Professor Derek Bowie – McGill University


11.15 AM        Dr Andrew Marks – Columbia University

Structure and function of ryanodine receptor in disease of heart and skeletal muscle


11.40 AM        Dr Vera Moiseenkova-Bell – University of Pennsylvania

Molecular Mechanisms of TRPV Channels Gating Revealed by Cryo-EM


12.05 PM        Dr Paul Colussi – Tetragenetics 

Discovery of functional monoclonal antibodies against Kv1.3 and kCa3.1 using the TetraExpressTM protein expression platform


12.30 PM        Lunch


Session 3 – Professor Diane Lipscombe – Brown University


02.00 PM        Professor Al George – Northwestern University

Decrypting human ion channel variants of unknown significance


02.25 PM        Professor Geoffrey Abbott – University of California, Irvine

Direct activation of potassium channels by neurotransmitters and ancient medicines


02.50 PM        Dr Anna Greka – Broad Institute of MIT

Ion channel targeted therapy for rare disease


03.15 PM        Professor Bruce Bean – Harvard

Strategies for selective neuronal inhibition 


03.40 PM        Reception and Poster Session

05.30 PM        Drinks and buffet dinner



Day 2 – thursday

08.00 AM        Tea/coffee


09.00 AM        Welcome remarks


Session 4 – Dr John Dunlop – Amgen


09.05 AM        Dr Yonghong Bai – Amgen

Structural basis for pharmacological modulation of the TRPC6 channel elucidated by cryo-EM


09.30 AM        Professor Derek Bowie – McGill University

Structural underpinnings of ionotropic glutamate receptor activation


09.55 AM        Professor Len Kaczmarek – Yale University

Regulation of cellular signaling by potassium channels


10.20 AM        Tea/coffee – Exhibit and Posters Session


Session 5 – Dr John Dunlop – Amgen


11.00 AM        Professor Toshihisa Osaki – University of Tokyo

Artificial cell membrane platforms for functional analyses and drug screenings of ion channels


11.25 AM        Dr Owen McManus – Q-State Biosciences

Using optogenetic assays to identify sodium channel inhibitors as pain therapeutics


11.50 AM        Dr Saverio Gentile – University of Illinois

Potassium channel activity unveils cancer vulnerability: from signaling to precision medicine


12.15 PM        Lunch – Exhibits and Poster Session


Session 6 – Professor Derek Bowie – McGill University


01.15 PM        Professor Diane Lipscombe – Brown University

Epigenetic control of nociceptor-specific calcium channel splice isoforms in health and disease


01.40 PM        Dr Bryan Moyer – Amgen

Multi-modality approach to identify NaV1.7 inhibitors for pain


02.05 PM        Professor Amy Lee – University of Iowa

Voltage-gated Ca2+ channels of the retina: new insights into CaV1.4 channelopathies


02.30 PM        Tea/coffee


03.10 PM        Professor Ellen Lumpkin – University of California, Berkeley 

TTX-sensitive sodium channels mediate action potential firing in menthol-sensitive neurons of the dorsal root ganglion


03.35 PM        Dr Daniel Sauter – Sophion Bioscience

Towards more physiological assays: iPSC-derived neurons tested on the 384 channel automated patch clamp platform Qube


04.00 PM        Wrap up