The second quarter of 2020 has been special concerning the pandemic, lockdowns, and closed laboratories across the globe. However, Q2 has also been extraordinarily busy with published peer-review publications using QPatch and Qube 384.
Times fly. It is hard to believe that 20 years have passed since Sophion was founded but on 5th July we can celebrate our 20th anniversary and what a ride it’s been.
See the list of QPatch and Qube publications from Q1 2020.
Hope to see you in June 2021!
An increasing number of patents using Sophion patch-clamp data are published worldwide. Most of them are new compounds for therapeutic use, and we are more than delighted to support innovation in the field of drug discovery enabling “better and safer drugs, faster”
We used light stimulation to activate intracellular second messenger mechanism and recorded the electrophysiological response
A new Cav1.2 cell line from Charles River Laboratories tested on QPatch and Qube 384, show almost no rundown, resulting in trustworthy and reliable pharmacology
We regret to inform that due to COVID-19, the 5th Ion Channel Modulation Symposium in Cambridge, the United Kingdom, has been cancelled.
It also reduces data variability and ensures precise clamp compared to traditional standard methods.
Get the full recipe for executing adaptive protocols and applications hereof on Qube
During the COVID-19 pandemic, the need for remote training and support is larger than ever. For your convenience, we have therefore listed the tools we use for remote assistance to ensure our instruments and your research keeps running.
The new paper published by the CiPA consortium provides estimates of the variability of prominent human cardiac currents across five automated patch platforms and 17 sites.
The escalating outbreak of COVID-19 has affected each one of us in multiple ways, our families, friends, businesses and way of life. This fast-changing situation has forced us, to re-evaluate how we operate at Sophion Bioscience and adapt to the new situation. Click and read more
New possibilities to control the measurement sites on QPatch II
We are here to make sure you get your deliveries and the service you may require in spite of the current situation.
Whether you are experienced or a rookie user, this course will be relevant and adapted to your needs.
The Sophion User Meeting in Boston has been postponed to 22nd and 23rd September 2020
Learn more about how automated patch clamp can be used in personalized medicine, about ion channels in cancer or about our new feature ‘Adaptive Protocols’.
Tighter data and more confidence in detecting mode-of-action in HTS
Come and see us at BPS in San Diego in February – find us at booth #600
We have demonstrated the stability of V½ over multiple liquid periods and reliable pharmacology
Several new posters from SPS in Barcelona from NMI, Eurofins, Metrion, Nissan chemical, and iSMART, emphasizes the QPatch as the benchmark APC solution for cardiac safety
We have gathered the posters from ICMS on our website. From Sanofi, Charles River Laboratories, LifeArc, Unis of Leeds, Uni of Cambridge and off course a few from Sophion. Check them out
Effect of culture duration, biophysical properties and neurological disease phenotyping
Expand your throughput in cardiac safety profiling
High performance, high throughput e-phys with preserved intracellular milieu. See our newest application report and learn how to do perforated patch clamp on Qube 384
New Nav1.5 assay that delivers improved cardiac safety screening reliability and cost.
Another Ph.D.student has successfully finalized his study
Imagine your laboratory testing over 4,000 wells with high fidelity electrophysiology while you are at home
Learn more about ion channels and cancer, how our patch clamp systems can characterize ALS disease models and much more
Sign up to our mailing list and get access to the latest ion channel news and events.
Repetitive and stable responses in 384 format which enables demonstration of subtype selective pharmacology on a large scale
Training course at a Sophion lab near you
Both ligand- and voltage-gated targets can be screened on Qube 384
Adaptive protocols and integrated temperature control
Wnt ligands binding to the cell membrane receptors lead to intracellular Ca2+ release and the early events in this signalling pathway was investigated by using QPatch and single cell patch recording.
Neurological disease models characterized
Biophysical and pharmacological profiling of multiple voltage-gated sodium channel subtypes. The study used QPatch ll in combination with adaptive voltage protocols to investigate state-dependent inhibition of tetrodotoxin (TTX), amitriptyline and tetracaine on 8 different VGSC subtypes (Nav1.1-8).
Third commercially available Cav1.2 cell line which behaves stably on Qube
Looking back at 2018 it was another year that was fun and rewarding, but also extremely busy
Sending you the warmest thoughts and best wishes for a wonderful Holiday and a Happy New Year
We are happy to assist in making the Brisbane Pain Research symposium a success
Ligand-activation of GABAA receptors on QPatch and Qube 384 using conventional electrophysiology and optopharmacology . Pharmacological responses of the GABA receptor GABAA (ɑ5β3γ2), stably expressed in a HEK cell line, and in primary hippocampal astrocytes.
Six posters all with results from Qube and QPatch was presented at SPS in Washington DC covering cardiac safety channels
70th Annual Meeting of the Korean Physiological Society
Electrophysiological properties of hiPSCs from Spinal Muscular Atrophy (SMA) or Amyotrophic Lateral Sclerosis (ALS) patients was measured and compared to their control cell lines
Another great Sophion seminar was held in Japan with more than 40 users from Japan and South Korea
Drop by our booth at SfN and get a live demo
Many new and interesting papers are available. Enjoy your reading
Sophisticated structure-activity relationship revealed
Let it run during night
Great interest from current and future QPatch users at SPS in Washington
We have together with Metrion Biosciences implemented the challenging Milnes hERG cardiac safety assay on QPatch.
We have been busy and so have our partners. 11 new peer reviewed publications, 7 new posters, 5 new application reports from the last couple of months. Enjoy.
After more than ten years of success with QPatch, we are raising the bar again. Come and see the QPatch II at this years SPS in Washington DC (30 sept-2 Oct)
Did you miss the Ion Channel Modulation Symposium in June? Well, don’t despair
Another great symposium, this time in China. It was a pleasure for us at Sophion to co-organize this event and we were happy to see the large attendance from engaged researchers.
Join us for a couple of days of great QPatch and Qube talks and good company.
We are so happy to announce that our Japanese website now is live.
ICMS2018 – huge thanks from the Sophion team to everyone who attended.
Optogenetics combined with microfluidic channels is a powerful combination when a short ligand exposure time is needed. Here we have tested both instantaneous washout and washout after 500 milliseconds to achieve ultrashort GABA responses on the Qube Opto 384.
Here we go again… another statement on privacy. We will continue to handle your personal information with integrity and respect
A reproducible QPatch assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel
Counting down to Sophion Ion Channel Modulation Symposium 2018
Pharmacological manipulation of the GABA ion channel has a large potential. The central role of GABA in the nervous system is underscored by the devastating consequences of pathophysiological changes in GABA signalling. Conversely, manipulation of GABA receptors can offer relief of a large group of neurological and psychiatric disorders.
GABA mediated currents elicited by optical uncaging in both a concentration and light dependant fashion.
QPatch studies on voltage- and current clamp recordings on Cor.4U human iPS cell-derived cardiomyocytes
Two days training is enough
Patch clamp and optogenetics – Discover the Qube with 384 integrated and adjustable LEDs for advanced optogenetic measurements
Mode-of-action pharmacology in real unattended high-fidelity HTS
Please welcome Thomas Byrne to the North American team as our new Technical Service Engineer based in Boston!
Get the power to analyze the Qube data generated by your external partner
A reproducible high-throughput assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel
Drop by our booth #518 and meet with our experts to discuss your ion channel needs.
For Sophion it has been a year with many changes, a lot of news and countless achievements. It has also, by far, been the best year in the history of Sophion Bioscience……
Wish you a successful and happy New Year
The places fill up quickly so please make sure to register ASAP!
More systems ready to ship to customers
Short ligand exposure time (0.8 s) counteracts channel desensitization on nAChRa1
It is great to see the current high publication activity with our QPatch system worldwide.
Double up on space in Sophion Japan
Qube, an ideal tool for profiling large compound libraries on voltage-gated sodium channels.
Mark your calendar for the Sophion Ion Channel Modulation Symposium 2018
A lot of new peer reviewed publications have seen the light over the summer. Here is some selected new publications. For more interesting publilcations on QPatch and Qube you can always search our publication database
Temperature effect on hERG channel pharmacology measured using the Qube automated patch clamp system
We are staffing up again. We have hired two new application specialists to meet the increasing demand of new application development and customer support. Meet Dr. Kadla Røskva Rosholm and Dr. Kim Boddum at customer sites, demos or conferences.
Some like it slow, some like it fast. A Qube user wanted faster washout of activator in ligand gated experiments and contacted their application scientist.
Article from Tecan about Sophion and QPatch: OEM instrument design offers automated patch clamping solution
Did you miss the Sophion Ion Channel Modulation Symposium in Cambridge in June?
Enjoy current clamp combined with voltage clamp in the same sweep and on all 384 sites to make you results very tight. Cool or heat at the recording site to investigate the temperature sensitivity of the pharmacology you are interested in. Load Qube with stock solutions and let it dilute it to the final test …
Significant temperature sensitivity of hERG pharmacology revealed with Qube 384 temperature controlled recordings
Sophion Bioscience has been acquired by Sophion CEO Thais T. Johansen, its management and a group of experienced investors.
Sophion Bioscience, Inc. are now all settled their news office in Boston.
Another great Sophion Ion Channel Modulation Symposium meeting at the amazing Clare College. Knowledge sharing, socializing and presentations of new discoveries in our field from the top notch researchers from academia and pharma industry. …. and good food and beer not to mention. Great way to spend a week. ICMS2018 already in pipeline.
PhD summer school on cardiac electrophysiology with 30 students from across Europe
Inhibitory effect of some established Atrial Fibrillation drugs on SK channels
Traditional Japanese Kampo medicine compound improves opioid-induced constipation in rats by activating cystic fibrosis transmembrane conductance regulator.
Knotbodies as therapeutic agents – concentration-dependent inhibition of Kv1.3 and ASIC1a currents demonstrated using QPatch automated patch clamp.
Internal addition of compounds targeting the chloride channel CIC-1. A robust assay with good pharmacology and high Z-score
New Sophion offices and laboratory in Boston
New QPatch paper in Nature/Scientific data proves the feasibility of automated electrophysiological characterization of neuronal cells
We are working with the final details for this years’ agenda and we are very proud of the line up. Again this year we have a good programme with excellent speakers and interesting topics. You can see the agenda here.
Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes.
Stable Cav1.2 recordings on Qube 384 – a robust assay with high success rate and reliable pharmacology