New poster presents different depletion strategies for activation of CRAC channel current on QPatch and (Qube).
Sophion automated patch clamp users have been publishing 28 publications in Q1 and 17 in Q2
A call to arms for action on the challenge of an aging population and the lack of safety assessment in medicines for this growing demographic.
An extensive review in Frontiers co-authored by Sophion Bioscience and the University of Göttingen highlights big strides in our understanding of ion channels.
New application report highlights the importance of temperature on the activity and pharmacology of hERG
To watch the May 19th webinar, click here
The power of phage display used to discover antibodies to neutralize snake toxins, is creating a new generation of engineered, tailored antivenom to treat snakebite.
Join us for yet another webinar on Automated Patch Clamp and iPSC. This time with focus on cellular, molecular and electrophysiological characterization of CDKL5 deficiency disorder in iPSC-derived neurons.
A new application report highlights the possibility to obtain automated patch clamp (APC) ion channel recordings modulated by the fragile and scarce Wnt proteins. Wnt 9B, 5A and 10B, were all shown to activate ion channel currents in PC3 cells.
In case you missed the webinar on 15th March, you can watch it here
First publication from Yale; more venom toxin research from University of Queensland; Qube stem cell studies taking off
Nanyang Technological University, Singapore, advances research on ion channels in disease and immunity with QPatch II
hiPSC-cardiomyocyte current clamp action potential recordings
Sophion announces support for young scientists to present or generate data
Come by booth #1641 to discover more about QPatch Compact, our alternative to manual patch clamping
View or review our webinar from last week on APC and large molecules
The ready-to-use QPatch Compact solution lets you conduct experiments with fast and easier access to all your patch-clamp data. Take advantage of the flexibility in manual patch clamping and benefit from the robustness, ease, and simplicity of automated patch clamping with QPatch Compact.
In the first of many, the Waxman lab has published its first Qube paper
Sending the warmest thoughts and best wishes for a Wonderful Holiday and a Happy New Year – click to see our greeting
Scientists are busy and productive people. We have gathered 10 brand new publications using QPatch and Qube that were published in Q3.
The electrophysiological characterization included voltage-gated recordings and paced action potential measurements, all performed on hiPSC cardiomyocytes
Again this year, there is plenty of interesting content at SfN for Ion Channel aficionados. Check out these three virtual poster presentations on large molecule drug discovery and stem cell characterization.
Pharmacological characterization of charybdotoxin evaluated on Qube in fluoride-free solutions
“[QPatch II] enables us to carry out experiments around 48 times more rapidly. Work that normally takes a year can be completed in approximately a week … it will enable us to open up new territory”
In collaboration with the University of Göttingen generated QPatch II recordings of cardiomyocytes with a fantastic result
Discovery and development of a monoclonal antibody to neutralize Cobra venom
In a Marie Curie funded collaboration with the University of Birmingham, UK, Sandra Wilson has co-authored a paper on the potential effects of nanomaterials crossing the blood brain barrier
Daniel Sauter recently gave a talk on ‘Ion Channel Drug Discovery’ at Universidad De La Salle Bajio, Mexico. Watch the recording on Facebook or contact us if you would like us to do similar educational talks at your institution.
Internship poster presents plant cell ion channel recordings on QPatch II
DTU researchers discuss their latest findings in developing antibodies to neutralize snake venom toxins
A case study on how Enterprise Therapeutics successfully applied automated patch clamp in primary screening and lead optimization in its TMEM16A drug discovery programme
Full integration of Qube 384 and QPatch II data to Genedata Screener will ensure that APC data can be analyzed in a screening context, i.e., integrated with molecule and assay property information, scaling from one to hundreds of plates per batch.
Sophion Japan collaborated with Toho University on Oseltamivir an anti-afibrillatory; a review of APC in cardiac safety assessment.
This years’ ICMS will be virtual. Mark your calendar.
Are you in Switzerland and interested in automated electrophysiology?
We are happy to announce our brand new update on Sophion Analyzer
Cardiac safety testing of antimalarials repurposed as potential Covid-19 treatments; modulator chemistry of Kv7/M-channels & their diseases; transient expression of chronic pain related Cav2.2 & Nav1.7 channels.
Mark your calendar for our next virtual User Meeting
9 new publications were published in Q4 using QPatch or Qube 384. Two book chapters in the Springer-Nature published methods book ‘Patch Clamp Electrophysiology’ (co-edited by Drs. Mark Dallas & Damian Bell) were written by Sophion scientists, one on Qube perforated patch-clamp, the other on optogenetics using the Opto Qube 384. These chapters add to …
Nav- and Kv-channels quantified in cortical neurons and a patient population
…go for a tour in the Sophion Laboratory to learn more about our APC solutions, events, publications, amplifiers etc etc. You can bring coffee
Screen with high success rates and large screening window
Join us for the virtual satellite meeting Drug Discovery for Ion Channels XXII
ApconiX upgrade their APC capabilities with a QPatch ll 48 to meet the increasing demand for high-quality data
Predatory marine cone snails and the effect of CBD (Cannabis) on seven major cardiac currents. The topics are diverse in the 12 publications using QPatch or Qube 384 that were published in peer-reviewed papers in Q3 2020.
SK Biopharma is the first company to purchase a Sophion APC system in South Korea
The unique design of our QPlates provides many advantages. Among others 100% liquid exchange, giga-seals in physiological solutions and no need for electrode maintenance. In this application report, we tell about the design and advantages of using microflow-based consumables for Automated Patch Clamp. Learn how the QPlate materials make it possible to create giga-ohm seals …
Join us for a webinar on APC in Academia and learn about the dos & dos
As editors of ‘Patch Clamp Electrophysiology’, part of Springer Nature’s highly successful Methods in Molecular Biology series, Mark Dallas (University of Reading) and Damian Bell (Sophion) scoured the globe to find experts to share their practical experience in ion channel recordings.
The ion channel field is an extremely exciting and rapidly expanding area of study and with the adoption of automated patch-clamp (APC) technology, a wealth of opportunity has been created for those who choose a career in this arena. Join us for this free event.
Screen with high success rates and large screening window
An interview about automated patch clamp, academic collaborations and why we are using all those Q’s in our names.
Reduced cell volume still ensure high success rates on Qube and QPatch ll
Ion channel research requires high fidelity patch-clamping
RTU cells ignite your experiment within minutes
We are happy to announce that Damian Bell will be joining the Sophion team beginning October 1st 2020
On Tuesday, September 23rd, the NA team at Sophion put together our first Virtual User Meeting, typically held onsite at the Hilton in Woburn and at the Woburn Lab, using WebEx
Dr. Stephen Waxman and the ‘Center for Neuroscience and Regeneration Research’ at Yale School of Medicine and the Veterans Affairs West Haven Medical Center have acquired automated patch-clamp and are installing both a Qube 384 and a QPatch II 48.
Tighter data with further developed adaptive protocols
While the pandemic has closed down many laboratories, publication activities using QPatch and Qube has gone through the roof.
We have another 20th anniversary this year. Join us in congratulating Jørgen Due on his work anniversary.
Join us for the very first virtual Sophion User Meeting on 22nd September.
…and will in the future also have people on the ground in California, so it will be easier to get support and on-site visit on the west coast. Read more….
The second quarter of 2020 has been special concerning the pandemic, lockdowns, and closed laboratories across the globe. However, Q2 has also been extraordinarily busy with published peer-review publications using QPatch and Qube 384.
Times fly. It is hard to believe that 20 years have passed since Sophion was founded but on 5th July we can celebrate our 20th anniversary and what a ride it’s been.
See the list of QPatch and Qube publications from Q1 2020.
Hope to see you in June 2021!
An increasing number of patents using Sophion patch-clamp data are published worldwide. Most of them are new compounds for therapeutic use, and we are more than delighted to support innovation in the field of drug discovery enabling “better and safer drugs, faster”
We used light stimulation to activate intracellular second messenger mechanism and recorded the electrophysiological response
A new Cav1.2 cell line from Charles River Laboratories tested on QPatch and Qube 384, show almost no rundown, resulting in trustworthy and reliable pharmacology
We regret to inform that due to COVID-19, the 5th Ion Channel Modulation Symposium in Cambridge, the United Kingdom, has been cancelled.
It also reduces data variability and ensures precise clamp compared to traditional standard methods.
Get the full recipe for executing adaptive protocols and applications hereof on Qube
During the COVID-19 pandemic, the need for remote training and support is larger than ever. For your convenience, we have therefore listed the tools we use for remote assistance to ensure our instruments and your research keeps running.
The new paper published by the CiPA consortium provides estimates of the variability of prominent human cardiac currents across five automated patch platforms and 17 sites.
The escalating outbreak of COVID-19 has affected each one of us in multiple ways, our families, friends, businesses and way of life. This fast-changing situation has forced us, to re-evaluate how we operate at Sophion Bioscience and adapt to the new situation. Click and read more
New possibilities to control the measurement sites on QPatch II
We are here to make sure you get your deliveries and the service you may require in spite of the current situation.
Whether you are experienced or a rookie user, this course will be relevant and adapted to your needs.
Learn more about how automated patch clamp can be used in personalized medicine, about ion channels in cancer or about our new feature ‘Adaptive Protocols’.
Tighter data and more confidence in detecting mode-of-action in HTS
Come and see us at BPS in San Diego in February – find us at booth #600
We have demonstrated the stability of V½ over multiple liquid periods and reliable pharmacology
Several new posters from SPS in Barcelona from NMI, Eurofins, Metrion, Nissan chemical, and iSMART, emphasizes the QPatch as the benchmark APC solution for cardiac safety
We have gathered the posters from ICMS on our website. From Sanofi, Charles River Laboratories, LifeArc, Unis of Leeds, Uni of Cambridge and off course a few from Sophion. Check them out
Effect of culture duration, biophysical properties and neurological disease phenotyping
Expand your throughput in cardiac safety profiling
High performance, high throughput e-phys with preserved intracellular milieu. See our newest application report and learn how to do perforated patch clamp on Qube 384
New Nav1.5 assay that delivers improved cardiac safety screening reliability and cost.
Another Ph.D.student has successfully finalized his study
Imagine your laboratory testing over 4,000 wells with high fidelity electrophysiology while you are at home
Learn more about ion channels and cancer, how our patch clamp systems can characterize ALS disease models and much more
Sign up to our mailing list and get access to the latest ion channel news and events.
Repetitive and stable responses in 384 format which enables demonstration of subtype selective pharmacology on a large scale
Training course at a Sophion lab near you
Both ligand- and voltage-gated targets can be screened on Qube 384
Adaptive protocols and integrated temperature control
Wnt ligands binding to the cell membrane receptors lead to intracellular Ca2+ release and the early events in this signalling pathway was investigated by using QPatch and single cell patch recording.
Neurological disease models characterized
Biophysical and pharmacological profiling of multiple voltage-gated sodium channel subtypes. The study used QPatch ll in combination with adaptive voltage protocols to investigate state-dependent inhibition of tetrodotoxin (TTX), amitriptyline and tetracaine on 8 different VGSC subtypes (Nav1.1-8).
Third commercially available Cav1.2 cell line which behaves stably on Qube
Looking back at 2018 it was another year that was fun and rewarding, but also extremely busy
Sending you the warmest thoughts and best wishes for a wonderful Holiday and a Happy New Year
We are happy to assist in making the Brisbane Pain Research symposium a success
Ligand-activation of GABAA receptors on QPatch and Qube 384 using conventional electrophysiology and optopharmacology . Pharmacological responses of the GABA receptor GABAA (ɑ5β3γ2), stably expressed in a HEK cell line, and in primary hippocampal astrocytes.
Six posters all with results from Qube and QPatch was presented at SPS in Washington DC covering cardiac safety channels
70th Annual Meeting of the Korean Physiological Society
Electrophysiological properties of hiPSCs from Spinal Muscular Atrophy (SMA) or Amyotrophic Lateral Sclerosis (ALS) patients was measured and compared to their control cell lines
Another great Sophion seminar was held in Japan with more than 40 users from Japan and South Korea
Drop by our booth at SfN and get a live demo
Many new and interesting papers are available. Enjoy your reading
Sophisticated structure-activity relationship revealed
Let it run during night
Great interest from current and future QPatch users at SPS in Washington
We have together with Metrion Biosciences implemented the challenging Milnes hERG cardiac safety assay on QPatch.
We have been busy and so have our partners. 11 new peer reviewed publications, 7 new posters, 5 new application reports from the last couple of months. Enjoy.
After more than ten years of success with QPatch, we are raising the bar again. Come and see the QPatch II at this years SPS in Washington DC (30 sept-2 Oct)
Did you miss the Ion Channel Modulation Symposium in June? Well, don’t despair
Another great symposium, this time in China. It was a pleasure for us at Sophion to co-organize this event and we were happy to see the large attendance from engaged researchers.
Join us for a couple of days of great QPatch and Qube talks and good company.
We are so happy to announce that our Japanese website now is live.
ICMS2018 – huge thanks from the Sophion team to everyone who attended.
Optogenetics combined with microfluidic channels is a powerful combination when a short ligand exposure time is needed. Here we have tested both instantaneous washout and washout after 500 milliseconds to achieve ultrashort GABA responses on the Qube Opto 384.
Here we go again… another statement on privacy. We will continue to handle your personal information with integrity and respect
A reproducible QPatch assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel
Counting down to Sophion Ion Channel Modulation Symposium 2018
Pharmacological manipulation of the GABA ion channel has a large potential. The central role of GABA in the nervous system is underscored by the devastating consequences of pathophysiological changes in GABA signalling. Conversely, manipulation of GABA receptors can offer relief of a large group of neurological and psychiatric disorders.
GABA mediated currents elicited by optical uncaging in both a concentration and light dependant fashion.
QPatch studies on voltage- and current clamp recordings on Cor.4U human iPS cell-derived cardiomyocytes
Two days training is enough
Patch clamp and optogenetics – Discover the Qube with 384 integrated and adjustable LEDs for advanced optogenetic measurements
Mode-of-action pharmacology in real unattended high-fidelity HTS
Please welcome Thomas Byrne to the North American team as our new Technical Service Engineer based in Boston!
Get the power to analyze the Qube data generated by your external partner
A reproducible high-throughput assay with high success rates for biophysical and pharmacological studies of the Cav1.2 channel
Drop by our booth #518 and meet with our experts to discuss your ion channel needs.
For Sophion it has been a year with many changes, a lot of news and countless achievements. It has also, by far, been the best year in the history of Sophion Bioscience……
Wish you a successful and happy New Year
The places fill up quickly so please make sure to register ASAP!
More systems ready to ship to customers
Short ligand exposure time (0.8 s) counteracts channel desensitization on nAChRa1
It is great to see the current high publication activity with our QPatch system worldwide.
Double up on space in Sophion Japan
Qube, an ideal tool for profiling large compound libraries on voltage-gated sodium channels.
Mark your calendar for the Sophion Ion Channel Modulation Symposium 2018
A lot of new peer reviewed publications have seen the light over the summer. Here is some selected new publications. For more interesting publilcations on QPatch and Qube you can always search our publication database
Temperature effect on hERG channel pharmacology measured using the Qube automated patch clamp system
We are staffing up again. We have hired two new application specialists to meet the increasing demand of new application development and customer support. Meet Dr. Kadla Røskva Rosholm and Dr. Kim Boddum at customer sites, demos or conferences.
Some like it slow, some like it fast. A Qube user wanted faster washout of activator in ligand gated experiments and contacted their application scientist.
Article from Tecan about Sophion and QPatch: OEM instrument design offers automated patch clamping solution
Did you miss the Sophion Ion Channel Modulation Symposium in Cambridge in June?
Significant temperature sensitivity of hERG pharmacology revealed with Qube 384 temperature controlled recordings
Sophion Bioscience has been acquired by Sophion CEO Thais T. Johansen, its management and a group of experienced investors.
Sophion Bioscience, Inc. are now all settled their news office in Boston.
Another great Sophion Ion Channel Modulation Symposium meeting at the amazing Clare College. Knowledge sharing, socializing and presentations of new discoveries in our field from the top notch researchers from academia and pharma industry. …. and good food and beer not to mention. Great way to spend a week. ICMS2018 already in pipeline.
PhD summer school on cardiac electrophysiology with 30 students from across Europe
Inhibitory effect of some established Atrial Fibrillation drugs on SK channels
Traditional Japanese Kampo medicine compound improves opioid-induced constipation in rats by activating cystic fibrosis transmembrane conductance regulator.
Knotbodies as therapeutic agents – concentration-dependent inhibition of Kv1.3 and ASIC1a currents demonstrated using QPatch automated patch clamp.
Internal addition of compounds targeting the chloride channel CIC-1. A robust assay with good pharmacology and high Z-score
New Sophion offices and laboratory in Boston
New QPatch paper in Nature/Scientific data proves the feasibility of automated electrophysiological characterization of neuronal cells
We are working with the final details for this years’ agenda and we are very proud of the line up. Again this year we have a good programme with excellent speakers and interesting topics. You can see the agenda here.
Action potentials are induced in both HL-1 mouse atrial cardiomyocytes and Axiogenesis Cor.4U iPS cell-derived cardiomyocytes.
Stable Cav1.2 recordings on Qube 384 – a robust assay with high success rate and reliable pharmacology