New papers, posters and reports from Q1 2019

Learn more about how you can use Sophion patch clamp to characterize iPSC-Derived Motor Neurons in ALS disease models. Learn about our optogenetic Qube, ion channels in cancer, and much more from academic and pharma researchers, from among others Amgen, Axxam, Sanofi, Kings College London, BrainXell etc.


Peer-reviewed papers

D Wang et al 2018. Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Mar. Drugs, 16(12), 475

B Kaproń et al 2018. Development of the 1,2,4-triazole-based anticonvulsant drug candidates acting on the voltage-gated sodium channels. Insights from in-vivo, in-vitro, and in-silico studies. European Journal of Pharmaceutical Sciences Vol 129, Pages 42-57

S Yadav et al 2018. Benzothiophenes as Potent Analgesics Against Neuropathic Pain. Biochemical and Biophysical Roles of Cell Surface Molecules, Advances in Experimental Medicine and Biology 1112

Reyes-Corral et al 2019. Differential Free Intracellular Calcium Release by Class II Antiarrhythmics in Cancer Cell Lines. The Journal of Pharmacology and Experimental Therapeutics [17 Jan 2019, 369(1):152-162]

Miner et al 2019. Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways. Frontiers in Pharmacology, Vol 10, Article 51

Das et al 2019. Novel Chitohexaose Analog Protects Young and Aged mice from CLP Induced Polymicrobial Sepsis. Nature Scientific Reports, Vol 9, Article 2904

Sanson et al 2019. Electrophysiological and Pharmacological Characterization of Human Inwardly Rectifying Kir2.1 Channels on an Automated Patch-Clamp Platform. Assay Drug Dev Technol. 2019 Mar

Bagchi et al 2019. Disruption of Myelin Leads to Ectopic Expression of KV1.1 Channels with Abnormal Conductivity of Optic Nerve Axons in a Cuprizone-Induced Model of Demyelination


Sauter et al 2019. Biophysical and Pharmacological Profiling of Multiple Voltage-Gated Sodium Channel Subtypes on QPatch II. Poster, Biophysics 2019

Rosholm & Schupp 2019. iPSC-Derived Motor Neurons on the Automated Patch Clamp Platforms Qube and QPatch. Poster, Biophysics 2019

Boddum et al 2019. Optical modulation of ion channels using Qube Opto. Poster, Mammalian Sensory Systems 2019

Application Reports:

Boddum, Korsgaard 2019. Pharmacological evaluation of GABAA receptor subtypes on Qube 384. Sophion Application Report